ArticleFrontiers in neurology2011
Treatment of Essential Tremor: Are there Issues We are Overlooking?
Article in Frontiers in neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Loss of long-term benefit from VIM-DBS in essential tremor: A secondary analysis of repeated measurements.CNS neuroscience & therapeutics · 2022Pooled it
- Does non-invasive brain stimulation reduce essential tremor? A systematic review and meta-analysis.PloS one · 2017Pooled it
- Comparative Effectiveness of Transcutaneous Afferent Patterned Stimulation Therapy for Essential Tremor: A Randomized Pragmatic Clinical Trial.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Trial
- Tremor Recurrence in MR-Guided Focused Ultrasound Thalamotomy for Essential Tremor: DBS vs. Re-lesion.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review.NeuroSci · 2024Review
- Spatial Augmented Reality for Expanding the Reach of Individuals with Tremor beyond Their Physical Limits.Sensors (Basel, Switzerland) · 2024Article
- Associations Among Tremor Amplitude, Activities of Daily Living, and Quality of Life in Patients with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Supporting Tremor Rehabilitation Using Optical See-Through Augmented Reality Technology.Sensors (Basel, Switzerland) · 2023Article
- Classification of Kinematic and Electromyographic Signals Associated with Pathological Tremor Using Machine and Deep Learning.Entropy (Basel, Switzerland) · 2023Article
- Transcutaneous Afferent Patterned Stimulation for Essential Tremor: Real-World Evidence with Long Term Follow-Up.Tremor and other hyperkinetic movements (New York, N.Y.) · 2023Article
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Non-invasive suppression of essential tremor via phase-locked disruption of its temporal coherence.Nature communications · 2021Article
- Selective loss of the GABAJournal of neurophysiology · 2020Article
- Optimal Parameters of Deep Brain Stimulation in Essential Tremor: A Meta-Analysis and Novel Programming Strategy.Journal of clinical medicine · 2020Article
- Article
- Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society.Movement disorders : official journal of the Movement Disorder Society · 2018Review
- MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor.Journal of visualized experiments : JoVE · 2017Article
- Awareness of cognitive impairment in individuals with essential tremor.Journal of the neurological sciences · 2017Article
- Current and emerging brain applications of MR-guided focused ultrasound.Journal of therapeutic ultrasound · 2017Review
- Focused Ultrasound for Essential Tremor: Review of the Evidence and Discussion of Current Hurdles.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundEssential tremor (ET) is one of the most common neurological diseases. Although a large number of medications have been tested, there are only two first-line medications, primidone and propranolol, which is a situation that has not changed in approximately 30 years. Several recent reviews have summarized the current pharmacotherapeutic options for ET and the approach to the management of ET patients. Yet there remain a number of important issues, both scientific and clinical, that have not been broached in the literature and that have therapeutic implications.
objectivesTo introduce several clinical and scientific issues that have not formally entered the published literature on the treatment of ET.
methodsIn September 2011, materials for this article were gathered during a literature search of PubMed using the following terms: ET, clinical, clinical trial, treatment, medications, therapeutics. English-language articles were selected for further review.
resultsThe paper focuses on several topics that have received scant or no discussion in the published literature on ET therapeutics. These topics are as follows: the nature of the underlying disease pathophysiology, the presence of pathological heterogeneity, the complexity of cellular and neurochemical changes which may be underlying this disorder, the presence of clinical heterogeneity, the selection of treatment endpoints, the effects of diagnostic uncertainty, the presence of cognitive and psychiatric features in ET, the identification of possible modifiable risk factors, and the absence of any neuroprotective therapies.
conclusionThe author has identified several topics that have received scant or no discussion in the published literature on ET therapeutics. Further discussion of the issues raised here may lead to improvements in clinical trial methodologies as well as facilitate the development of fresh approaches to pharmacotherapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.