ArticleFrontiers in neuroinformatics2011
An in vivo MRI Template Set for Morphometry, Tissue Segmentation, and fMRI Localization in Rats.
Article in Frontiers in neuroinformatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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Who cites it
115 citing papers in PubMed.
- Effects of THC, CBD, and Their Combination on EEG Dynamics in Rats.Physiological research · 2026Article
- Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation.Science advances · 2026Article
- Acute cannabidiol (CBD), tetrahydrocannabinol (THC) and their mixture (THC:CBD) exert differential effects on brain activity and blood flow in rats: A translational neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2026Article
- Post-traumatic osteoarthritis in aged rodents is associated with brain changes that correlate with joint remodeling.The journal of pain · 2026Article
- Interoception network in the rat brain.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- A brain-state-informed framework for simultaneous extinction of fear and functional magnetic resonance imaging acquisition in rodents.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Microstate in rats' EEG: a proof of concept study.Translational psychiatry · 2025Article
- Investigating the Limits of Predictability of Magnetic Resonance Imaging-Based Mathematical Models of Tumor Growth.Cancers · 2025Article
- Unbiased population-based statistics to obtain pathologic burden of injury after experimental TBI.Experimental neurology · 2025Article
- Unbiased Population-Based Statistics to Obtain Pathologic Burden of Injury after Experimental TBI.bioRxiv : the preprint server for biology · 2025Article
- Intrinsic brain network stability during kainic acid-induced epileptogenesis.Epilepsia open · 2025Article
- Review
- Distinct neurochemical influences on fMRI response polarity in the striatum.Nature communications · 2024Article
- EiDA: A lossless approach for dynamic functional connectivity; application to fMRI data of a model of ageing.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Intrinsic Functional Connectivity between the Anterior Insular and Retrosplenial Cortex as a Moderator and Consequence of Cocaine Self-Administration in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- FUS-mediated BBB opening leads to transient perfusion decrease and inflammation without acute or chronic brain lesion.Theranostics · 2024Article
- Alterations in rat brain modular organization during unconsciousness are dependent on communication efficiency and metabolic cost.Brain structure & function · 2023Article
- Brain Response to Interferential Current Compared with Alternating Current Stimulation.Brain sciences · 2023Article
- Ultra-high-field pharmacological functional MRI of dopamine D1 receptor-related interventions in anesthetized rats.Pharmacology research & perspectives · 2023Article
- Addictive brain-network identification by spatial attention recurrent network with feature selection.Brain informatics · 2023Article
55 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
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Abstract
Over the last decade, several papers have focused on the construction of highly detailed mouse high field magnetic resonance image (MRI) templates via non-linear registration to unbiased reference spaces, allowing for a variety of neuroimaging applications such as robust morphometric analyses. However, work in rats has only provided medium field MRI averages based on linear registration to biased spaces with the sole purpose of approximate functional MRI (fMRI) localization. This precludes any morphometric analysis in spite of the need of exploring in detail the neuroanatomical substrates of diseases in a recent advent of rat models. In this paper we present a new in vivo rat T2 MRI template set, comprising average images of both intensity and shape, obtained via non-linear registration. Also, unlike previous rat template sets, we include white and gray matter probabilistic segmentations, expanding its use to those applications demanding prior-based tissue segmentation, e.g., statistical parametric mapping (SPM) voxel-based morphometry. We also provide a preliminary digitalization of latest Paxinos and Watson atlas for anatomical and functional interpretations within the cerebral cortex. We confirmed that, like with previous templates, forepaw and hindpaw fMRI activations can be correctly localized in the expected atlas structure. To exemplify the use of our new MRI template set, were reported the volumes of brain tissues and cortical structures and probed their relationships with ontogenetic development. Other in vivo applications in the near future can be tensor-, deformation-, or voxel-based morphometry, morphological connectivity, and diffusion tensor-based anatomical connectivity. Our template set, freely available through the SPM extension website, could be an important tool for future longitudinal and/or functional extensive preclinical studies.
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