ArticlePLoS pathogens2012
How "humane" is your endpoint? Refining the science-driven approach for termination of animal studies of chronic infection.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methodological standards, quality of reporting and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review.BMJ open science · 2019Pooled it
- Unraveling the mouse model ofMicrobiology spectrum · 2026Article
- Assessing laboratory animal welfare: the crucial importance of construct validity.Laboratory animals · 2026Article
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- Understanding the impact of moxifloxacin on immune function: Findings from cytokine analyses and immunological assays in mice.PloS one · 2025Article
- Contactless body temperature assessment for signalling humane endpoints in a mouse model of sepsis.Animal welfare (South Mimms, England) · 2025Article
- Article
- Using weight loss to predict outcome and define a humane endpoint in preclinical sepsis studies.Scientific reports · 2024Article
- Differential Immune Response Patterns Induced by Anionic and Cationic Lipid Adjuvants in Intranasal Anti-Influenza Immunization.Vaccines · 2024Article
- ImprovingF1000Research · 2024Article
- Hydro-ethanol extract of Holarrhena floribunda stem bark exhibits anti-anaphylactic and anti-oedematogenic effects in murine models of acute inflammation.BMC complementary medicine and therapies · 2022Article
- Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses complete Freund's adjuvant-induced arthritis in Sprague-Dawley rats.Journal of inflammation (London, England) · 2022Article
- An epithelialProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Refinement of Animal Model of Colorectal Carcinogenesis through the Definition of Novel Humane Endpoints.Animals : an open access journal from MDPI · 2021Article
- Reviewing the Review: A Pilot Study of the Ethical Review Process of Animal Research in Sweden.Animals : an open access journal from MDPI · 2021Article
- The Evidence for a Causal Link Between Disease and Damaging Behavior in Pigs.Frontiers in veterinary science · 2021Review
- Automated and Continuous Monitoring of Animal Welfare through Digital Alerting.Comparative medicine · 2020Article
- The use of 4-Hexylresorcinol as antibiotic adjuvant.PloS one · 2020Article
- Updating the modified Thompson test by using whole-body bioluminescence imaging to replace traditional efficacy testing in experimental models of murine malaria.Malaria journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.