ArticlePLoS computational biology2012
Prediction by promoter logic in bacterial quorum sensing.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Characterization of a Bacteriocin-like Substance fromVeterinary sciences · 2026Article
- From single cells to communities: Mathematical perspectives on bacterial quorum sensing.Computational and structural biotechnology journal · 2025Review
- Parameters, architecture and emergent properties of theJournal of the Royal Society, Interface · 2023Article
- Detection of Quorum-Sensing Molecules for Pathogenic Molecules Using Cell-Based and Cell-Free Biosensors.Antibiotics (Basel, Switzerland) · 2020Review
- Why do bacteria regulate public goods by quorum sensing?-How the shapes of cost and benefit functions determine the form of optimal regulation.Frontiers in microbiology · 2015Article
- A modular view of the diversity of cell-density-encoding schemes in bacterial quorum-sensing systems.Biophysical journal · 2014Article
- Using topology to tame the complex biochemistry of genetic networks.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2013Article
- A design principle of group-level decision making in cell populations.PLoS computational biology · 2013Article
- Interactions among quorum sensing inhibitors.PloS one · 2013Article
- Increasing signal specificity of the TOL network of Pseudomonas putida mt-2 by rewiring the connectivity of the master regulator XylR.PLoS genetics · 2012Article
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Authors and funding
7 authors.
Funding
Abstract
Quorum-sensing systems mediate chemical communication between bacterial cells, coordinating cell-density-dependent processes like biofilm formation and virulence-factor expression. In the proteobacterial LuxI/LuxR quorum sensing paradigm, a signaling molecule generated by an enzyme (LuxI) diffuses between cells and allosterically stimulates a transcriptional regulator (LuxR) to activate its cognate promoter (pR). By expressing either LuxI or LuxR in positive feedback from pR, these versatile systems can generate smooth (monostable) or abrupt (bistable) density-dependent responses to suit the ecological context. Here we combine theory and experiment to demonstrate that the promoter logic of pR - its measured activity as a function of LuxI and LuxR levels - contains all the biochemical information required to quantitatively predict the responses of such feedback loops. The interplay of promoter logic with feedback topology underlies the versatility of the LuxI/LuxR paradigm: LuxR and LuxI positive-feedback systems show dramatically different responses, while a dual positive/negative-feedback system displays synchronized oscillations. These results highlight the dual utility of promoter logic: to probe microscopic parameters and predict macroscopic phenotype.
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Registered trials
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