ArticlePLoS computational biology2012
Membrane properties and the balance between excitation and inhibition control gamma-frequency oscillations arising from feedback inhibition.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Beta power as a neural correlate of sensory features in autistic individuals.Journal of neurodevelopmental disorders · 2026Article
- Neuroglia's signaling: orchestrating neuronal gamma synchrony?Current opinion in neurology · 2025Review
- Changes in Early Aperiodic EEG Activity Are Linked to Autism Diagnosis and Language Development in Infants With Family History of Autism.Autism research : official journal of the International Society for Autism Research · 2025Article
- Changes in early aperiodic EEG activity are linked to autism diagnosis and language development in infants with family history of autism.medRxiv : the preprint server for health sciences · 2025Article
- Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs.Frontiers in neuroscience · 2025Article
- Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer's Disease.Translational neurodegeneration · 2024Review
- A 1-month ketogenic diet in patients with migraine gives a clinical beneficial effect associated with increased latency of somatosensory thalamo-cortical activity.Clinical neurophysiology practice · 2024Article
- From mechanisms to markers: novel noninvasive EEG proxy markers of the neural excitation and inhibition system in humans.Translational psychiatry · 2022Review
- Ketamine and Attentional Bias Toward Emotional Faces: Dynamic Causal Modeling of Magnetoencephalographic Connectivity in Treatment-Resistant Depression.Frontiers in psychiatry · 2021Article
- Paired Feed-Forward Excitation With Delayed Inhibition Allows High Frequency Computations Across Brain Regions.Frontiers in neural circuits · 2021Article
- Electrophysiological biomarkers of antidepressant response to ketamine in treatment-resistant depression: Gamma power and long-term potentiation.Pharmacology, biochemistry, and behavior · 2020Review
- Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies.Neural plasticity · 2020Article
- NCAM Regulates Inhibition and Excitability in Layer 2/3 Pyramidal Cells of Anterior Cingulate Cortex.Frontiers in neural circuits · 2017Article
- Article
- Cooperation and competition of gamma oscillation mechanisms.Journal of neurophysiology · 2016Article
- Firing rate dynamics in recurrent spiking neural networks with intrinsic and network heterogeneity.Journal of computational neuroscience · 2015Article
- Resonant Interneurons Can Increase Robustness of Gamma Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Brain extracellular matrix retains connectivity in neuronal networks.Scientific reports · 2015Article
- Short-term plasticity regulates the excitation/inhibition ratio and the temporal window for spike integration in CA1 pyramidal cells.The European journal of neuroscience · 2015Article
- Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability.Biological psychiatry · 2015Article
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2 authors.
Funding
Abstract
Computational studies as well as in vivo and in vitro results have shown that many cortical neurons fire in a highly irregular manner and at low average firing rates. These patterns seem to persist even when highly rhythmic signals are recorded by local field potential electrodes or other methods that quantify the summed behavior of a local population. Models of the 30-80 Hz gamma rhythm in which network oscillations arise through 'stochastic synchrony' capture the variability observed in the spike output of single cells while preserving network-level organization. We extend upon these results by constructing model networks constrained by experimental measurements and using them to probe the effect of biophysical parameters on network-level activity. We find in simulations that gamma-frequency oscillations are enabled by a high level of incoherent synaptic conductance input, similar to the barrage of noisy synaptic input that cortical neurons have been shown to receive in vivo. This incoherent synaptic input increases the emergent network frequency by shortening the time scale of the membrane in excitatory neurons and by reducing the temporal separation between excitation and inhibition due to decreased spike latency in inhibitory neurons. These mechanisms are demonstrated in simulations and in vitro current-clamp and dynamic-clamp experiments. Simulation results further indicate that the membrane potential noise amplitude has a large impact on network frequency and that the balance between excitatory and inhibitory currents controls network stability and sensitivity to external inputs.
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