ArticleCirculation research2012
Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells.
Article in Circulation research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 54 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 106 citations in OpenAlex.
- Unravelling the Interplay between Cardiac Metabolism and Heart Regeneration.International journal of molecular sciences · 2023Review
- Extracellular matrix from decellularized mesenchymal stem cells improves cardiac gene expressions and oxidative resistance in cardiac C-kit cells.Regenerative therapy · 2019Article
- Bradykinin-mediated CaJournal of cellular and molecular medicine · 2018Article
- Cardiac c-Kit Biology Revealed by Inducible Transgenesis.Circulation research · 2018Article
- Calcium-dependent potassium channels control proliferation of cardiac progenitor cells and bone marrow-derived mesenchymal stem cells.The Journal of physiology · 2018Article
- Recent Advances in Treatment of Coronary Artery Disease: Role of Science and Technology.International journal of molecular sciences · 2018Review
- SDF1 gradient associates with the distribution of c-Kit+ cardiac cells in the heart.Scientific reports · 2018Article
- The current status and future of cardiac stem/progenitor cell therapy for congenital heart defects from diabetic pregnancy.Pediatric research · 2018Review
- Short-term hypoxia improves early cardiac progenitor cell functionAmerican journal of stem cells · 2018Article
- Chasing c-Kit through the heart: Taking a broader view.Pharmacological research · 2018Review
- Regulation of the microenvironment for cardiac tissue engineering.Regenerative medicine · 2017Review
- Bradykinin regulates cell growth and migration in cultured human cardiac c-Kit+ progenitor cells.Oncotarget · 2017Article
- Novel direct reprogramming technique for the generation of culture-expandable cardiac progenitor cells from fibroblasts.Stem cell investigation · 2017Article
- Irx4 Marks a Multipotent, Ventricular-Specific Progenitor Cell.Stem cells (Dayton, Ohio) · 2016Article
- Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.Cell death & disease · 2016Article
- Developmental origin and lineage plasticity of endogenous cardiac stem cells.Development (Cambridge, England) · 2016Review
- Pharmacological Therapy in the Heart as an Alternative to Cellular Therapy: A Place for the Brain Natriuretic Peptide?Stem cells international · 2016Review
- Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart.Circulation research · 2015Article
- Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero.Nature communications · 2015Article
- cKit+ cardiac progenitors of neural crest origin.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
- Retraction · 2018-12-12Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Upgrade/Update of Prior Notice(s) ·
- Expression of concern · 2018-11-20Concerns/Issues about Data · Investigation by Company/Institution · Misconduct - Official Investigation(s) and/or Finding(s) · Updated to Retraction ·
- Expression of concern
- Expression of concern
- Retracted
Authors and funding
17 authors at 1 institution in 2 countries.
Funding
Abstract
rationaleEmbryonic and fetal myocardial growth is characterized by a dramatic increase in myocyte number, but whether the expansion of the myocyte compartment is dictated by activation and commitment of resident cardiac stem cells (CSCs), division of immature myocytes or both is currently unknown.
objectiveIn this study, we tested whether prenatal cardiac development is controlled by activation and differentiation of CSCs and whether division of c-kit-positive CSCs in the mouse heart is triggered by spontaneous Ca(2+) oscillations. METHODS AND
resultsWe report that embryonic-fetal c-kit-positive CSCs are self-renewing, clonogenic and multipotent in vitro and in vivo. The growth and commitment of c-kit-positive CSCs is responsible for the generation of the myocyte progeny of the developing heart. The close correspondence between values computed by mathematical modeling and direct measurements of myocyte number at E9, E14, E19 and 1 day after birth strongly suggests that the organogenesis of the embryonic heart is dependent on a hierarchical model of cell differentiation regulated by resident CSCs. The growth promoting effects of c-kit-positive CSCs are triggered by spontaneous oscillations in intracellular Ca(2+), mediated by IP3 receptor activation, which condition asymmetrical stem cell division and myocyte lineage specification.
conclusionsMyocyte formation derived from CSC differentiation is the major determinant of cardiac growth during development. Division of c-kit-positive CSCs in the mouse is promoted by spontaneous Ca(2+) spikes, which dictate the pattern of stem cell replication and the generation of a myocyte progeny at all phases of prenatal life and up to one day after birth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.