ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Neogenin regulates Sonic Hedgehog pathway activity during digit patterning.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Hippocampal astrocytic neogenin regulating glutamate uptake, a critical pathway for preventing epileptic response.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Polygenic Map of Keloid Fibroblasts Reveals Fibrosis-Associated Gene Alterations in Inflammation and Immune Responses.Frontiers in immunology · 2021Article
- Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation.Journal of molecular cell biology · 2020Article
- Neogenin in Amygdala for Neuronal Activity and Information Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior.Cell death & disease · 2018Article
- Article
- Neogenin Promotes BMP2 Activation of YAP and Smad1 and Enhances Astrocytic Differentiation in Developing Mouse Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol.Genes & nutrition · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDigit patterning integrates signaling by the Sonic Hedgehog (SHH), fibroblast growth factor (FGF), and bone morphogenetic protein (BMP) pathways. GLI3, a component of the SHH pathway, is a major regulator of digit number and identity. Neogenin (encoded by Neo1) is a cell surface protein that serves to transduce signals from several ligands, including BMPs, in various developmental contexts. Although neogenin is implicated in BMP signaling, it has not been linked to SHH signaling and its role in digit patterning is unknown.
resultsWe report that Neo1 mutant mice have preaxial polydactyly with low penetrance. Expression of SHH target genes, but not BMP target genes, is altered in Neo1 mutant limb buds. Analysis of mice carrying mutations in both Neo1 and Gli3 reveals that, although neogenin plays a role in constraint of digit numbers, suppressing polydactyly, it is also required for the severe polydactyly caused by loss of GLI3. Furthermore, embryo fibroblasts from Neo1 mutant mice are sensitized to SHH pathway activation in vitro.
conclusionsOur findings indicate that neogenin regulates SHH signaling in the limb bud to achieve proper digit patterning.
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