ArticleJournal of biomedical materials research. Part A2012
Bone turnover markers correlate with implant fixation in a rat model using LPS-doped particles to induced implant loosening.
Article in Journal of biomedical materials research. Part A, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Arthrotomy-based preclinical models of particle-induced osteolysis: A systematic review.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Pooled it
- Are there biological markers for wear or corrosion? A systematic review.Clinical orthopaedics and related research · 2014Pooled it
- Zucker Diabetic-Sprague Dawley Rats Have Impaired Peri-Implant Bone Formation, Matrix Composition, and Implant Fixation Strength.JBMR plus · 2023Article
- The relative contribution of bone microarchitecture and matrix composition to implant fixation strength in rats.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Ibudilast Mitigates Delayed Bone Healing Caused by Lipopolysaccharide by Altering Osteoblast and Osteoclast Activity.International journal of molecular sciences · 2021Article
- The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Early changes in serum osteocalcin and body weight are predictive of implant fixation in a rat model of implant loosening.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection.International journal of molecular sciences · 2020Article
- Periprosthetic Joint Infection Caused by Gram-Positive Versus Gram-Negative Bacteria: Lipopolysaccharide, but not Lipoteichoic Acid, Exerts Adverse Osteoclast-Mediated Effects on the Bone.Journal of clinical medicine · 2019Article
- Sophocarpine attenuates wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption via suppression of the NF-κB signalling pathway in a rat model.British journal of pharmacology · 2018Article
- Optimizing a micro-computed tomography-based surrogate measurement of bone-implant contact.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Article
- Intramembranous bone regeneration and implant placement using mechanical femoral marrow ablation: rodent models.BoneKEy reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Revision surgery for particle-induced implant loosening in total joint replacement is expected to increase dramatically over the next few decades. This study was designed to investigate if local tissue and serum markers of bone remodeling reflect implant fixation following administration of lipopolysaccharide (LPS)-doped polyethylene (PE) particles in a rat model. Twenty-four rats received bilateral implantation of intramedullary titanium rods in the distal femur, followed by weekly bilateral intra-articular injection of either LPS-doped PE particles (n = 12) or vehicle that contained no particles (n = 12) for 12 weeks. The group in which the particles were injected had increased serum C-terminal telopeptide of type I collagen (CTX-I), decreased serum osteocalcin (OC), increased peri-implant eroded surface, decreased peri-implant bone volume, and decreased mechanical pull-out strength compared to the controls. Implant fixation strength was positively correlated with peri-implant bone volume and serum OC and inversely correlated with serum CTX-I, while energy to yield was positively correlated with serum OC and inversely correlated with the number of tartrate-resistant acid phosphatase positive cells at the interface and the amount of peri-implant eroded surface. There was no effect on trabecular bone volume at a remote site. Thus, the particle-induced impaired fixation in this rat model was directly associated with local and serum markers of elevated bone resorption and depressed bone formation, supporting the rationale of exploring both anticatabolic and anabolic strategies to treat and prevent particle-related implant osteolysis and loosening, and indicating that serum markers may prove useful in tracking implant fixation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.