ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
VEGF 165 b in the developing vasculatures of the fetal human eye.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- VEGF and Neurotrophins Interaction in the Retinal Neurovascular Unit Homeostasis: A Target for Ocular Disease Treatment and Management.Pharmaceutical research · 2026Review
- Secondary glaucoma after bevacizumab injection in Type-1 retinopathy of prematurity.American journal of ophthalmology case reports · 2024Article
- Autophagy and Exocytosis of Lipofuscin Into the Basolateral Extracellular Space of Human Retinal Pigment Epithelium From Fetal Development to Adolescence.Investigative ophthalmology & visual science · 2024Article
- Human retinal secretome: A cross-link between mesenchymal and retinal cells.World journal of stem cells · 2023Review
- Integrative Single-Cell Transcriptomics and Epigenomics Mapping of the Fetal Retina Developmental Dynamics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Role of glucose metabolism in ocular angiogenesis (Review).Molecular medicine reports · 2022Review
- Exploring the Intracrine Functions of VEGF-A.Biomolecules · 2021Review
- Synergistic interactions of PlGF and VEGF contribute to blood-retinal barrier breakdown through canonical NFκB activation.Experimental cell research · 2020Article
- The VEGF-A exon 8 splicing-sensitive fluorescent reporter mouse is a novel tool to assess the effects of splicing regulatory compoundsRNA biology · 2019Article
- Vitreous Levels of Luteinizing Hormone and VEGF are Strongly Correlated in Healthy Mammalian Eyes.Current eye research · 2018Article
- Rb is required for retinal angiogenesis and lamination.Cell death & disease · 2018Article
- Development of the hyaloid, choroidal and retinal vasculatures in the fetal human eye.Progress in retinal and eye research · 2018Review
- WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-AAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAScientific reports · 2017Article
- Anti-VEGF therapy in the management of retinopathy of prematurity: what we learn from representative animal models of oxygen-induced retinopathy.Eye and brain · 2016Review
- Targeting VEGF in canine oxygen-induced retinopathy - a model for human retinopathy of prematurity.Eye and brain · 2016Article
- Nutrition and Vascular Supply of Retinal Ganglion Cells during Human Development.Frontiers in neurology · 2016Review
- VEGF mRNA and protein concentrations in the developing human eye.Pediatric research · 2015Article
- Short hairpin RNA-mediated knockdown of VEGFA in Müller cells reduces intravitreal neovascularization in a rat model of retinopathy of prematurity.The American journal of pathology · 2013Article
- SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity.Investigative ophthalmology & visual science · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
VEGF(165) b is an anti-angiogenic form of VEGF(165) produced by alternative splicing. The localization of pro-angiogenic VEGF(165) and anti-angiogenic VEGF(165) b was investigated during development of the vasculatures in fetal human eyes from 7 to 21 weeks gestation (WG). The fetal vasculature of vitreous, which includes tunica vasculosa lentis (TVL), had moderate VEGF(165) immunoreactivity at 7WG and very little VEGF(165) b. Both forms were elevated at 12WG. VEGF(165) then decreased around 17WG when the TVL regresses but VEGF(165) b remained elevated. In choroid, VEGF(165) was present in forming choriocapillaris (CC) and retinal pigment epithelium (RPE) at 7WG while VEGF165b was present in CC and mesenchymal precursors within the choroidal stroma. By 21WG, both forms were elevated in RPE and choroidal blood vessels but VEGF(165) b was apical and VEGF(165) basal in RPE. Diffuse VEGF(165) immunoreactivity was prominent in 12WG innermost retina where blood vessels will form while VEGF(165) b was present in most CXCR4(+) progenitors in the inner neuroblastic layer and migrating angioblasts in the putative nerve fiber layer. By 21WG, VEGF(165) was present in nerve fibers and VEGF(165) b in the inner Muller cell process. The localization of VEGF(165) b was distinctly different from VEGF(165) both spatially and temporally and it was often associated with nucleus in progenitors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.