ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2012
Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Sculpting the skull through neurosensory epithelial-mesenchymal signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2019Review
- Anatomic Malformations of the Middle and Inner Ear in 22q11.2 Deletion Syndrome: Case Series and Literature Review.AJNR. American journal of neuroradiology · 2018Review
- A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.Developmental biology · 2016Article
- Gene expression profiling of the inner ear.Journal of anatomy · 2016Review
- Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.Disease models & mechanisms · 2014Article
- Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat.PloS one · 2014Article
- Tbx1 is a negative modulator of Mef2c.Human molecular genetics · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding mesoderm of the periotic mesenchyme (POM) during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both the auditory and vestibular systems. We have previously reported that mesodermal Tbx1 loss of function mutants (Mest-KO) have reduced expression of retinoic acid (RA) metabolic genes, Cyp26a1 and Cyp26c1, in the POM, consistent with other studies showing an increase in mesodermal RA reporter expression in Tbx1-/- embryos. However, putative RA effector genes whose expression is altered downstream of increased otic mesenchymal-epithelial RA signaling have remained elusive.
resultsHere we report the identification of 18 retinoic acid responsive genes altered in Mest-KO conditional mutants by microarray gene profiling. Nine were chosen for biological validation including quantitative RT-PCR and in situ hybridization (Otor, Mia, Col2a1, Clu, Adm, Myt1, Dlx3, Itgb3, and Itga2b).
conclusionHere study provides a series of newly identified RA effector genes for inner ear development downstream of mesenchymal Tbx1 that may contribute to the inner ear phenotype observed in Tbx1 loss of function mouse models.
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