ArticleThe EMBO journal2012
Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex.
Article in The EMBO journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis.Current biology : CB · 2025Article
- The Caenorhabditis elegans Shugoshin regulates TAC-1 in cilia.Scientific reports · 2023Article
- The Borealin dimerization domain interacts with Sgo1 to drive Aurora B-mediated spindle assembly.Molecular biology of the cell · 2020Article
- A common molecular mechanism underlies the role of Mps1 in chromosome biorientation and the spindle assembly checkpoint.EMBO reports · 2020Article
- Article
- Phosphatases in Mitosis: Roles and Regulation.Biomolecules · 2019Review
- Budding yeast CENP-ACell cycle (Georgetown, Tex.) · 2018Article
- Article
- Distinct Roles of the Chromosomal Passenger Complex in the Detection of and Response to Errors in Kinetochore-Microtubule Attachment.Developmental cell · 2017Article
- Bub1 targeting to centromeres is sufficient for Sgo1 recruitment in the absence of kinetochores.Chromosoma · 2017Article
- The Ins and Outs of Aurora B Inner Centromere Localization.Frontiers in cell and developmental biology · 2017Review
- Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.Cell reports · 2015Article
- Shugoshins: tension-sensitive pericentromeric adaptors safeguarding chromosome segregation.Molecular and cellular biology · 2015Review
- Meiosis: an overview of key differences from mitosis.Cold Spring Harbor perspectives in biology · 2015Review
- The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.Frontiers in oncology · 2015Review
- STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.Journal of cell science · 2014Article
- Regulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosis.G3 (Bethesda, Md.) · 2014Article
- Tension-dependent removal of pericentromeric shugoshin is an indicator of sister chromosome biorientation.Genes & development · 2014Article
- Sgo1 regulates both condensin and Ipl1/Aurora B to promote chromosome biorientation.PLoS genetics · 2014Article
- Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere.eLife · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Shugoshins (Sgo) are conserved proteins that act as protectors of centromeric cohesion and as sensors of tension for the machinery that eliminates improper kinetochore-microtubule attachments. Most vertebrates contain two Sgo proteins, but their specific functions are not always clear. Xenopus laevis Sgo1, XSgo1, protects centromeric cohesin from the prophase dissociation pathway. Here, we report the identification of XSgo2 and show that it does not regulate cohesion. Instead, we find that it participates in bipolar spindle assembly. Both Sgo proteins interact physically with the Chromosomal Passenger Complex (CPC) containing Aurora B, a key regulator of mitosis, but the functional consequences of such interaction are distinct. XSgo1 is required for proper localization of the CPC while XSgo2 positively contributes to its activation and the subsequent phosphorylation of at least one key substrate for bipolar spindle assembly, the microtubule depolymerizing kinesin MCAK (Mitotic Centromere-Associated Kinesin). Thus, the two Xenopus Sgo proteins have non-overlapping functions in chromosome segregation. Our results further suggest that this functional specificity could rely on the association of XSgo1 and XSgo2 with different regulatory subunits of the PP2A complex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.