ReviewPharmaceutical research2012
Click chemistry with polymers, dendrimers, and hydrogels for drug delivery.
Review in Pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Click chemistry-based drug delivery systems for targeted cancer therapy.Materials today. Bio · 2026Review
- Click Chemistry for Biofunctional Polymers: From Observing to Steering Cell Behavior.Chemical reviews · 2024Review
- Advances in Hydrogel-Based Drug Delivery Systems.Gels (Basel, Switzerland) · 2024Review
- Controlled Sr(ii) ion release fromRSC advances · 2024Article
- Unlocking the potential of stimuli-responsive biomaterials for bone regeneration.Frontiers in pharmacology · 2024Review
- Click chemistry and drug delivery: A bird's-eye view.Acta pharmaceutica Sinica. B · 2023Review
- RAFT-Based Polymers for Click Reactions.Polymers · 2022Review
- Photoinduced Porcine Gelatin Cross-Linking by Homobi- and Homotrifunctional Tetrazoles.Gels (Basel, Switzerland) · 2021Article
- Disulfide-yne reaction: controlling the reactivity of a surface by light.RSC advances · 2021Article
- Article
- Peptide-Modified Biopolymers for Biomedical Applications.ACS applied bio materials · 2021Review
- Article
- Article
- In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications.Journal of functional biomaterials · 2019Article
- Biomedical applications of copper-free click chemistry:Chemical science · 2019Review
- Click-Engineered, Bioresponsive, and Versatile Particle-Protein-Dye System.ACS applied bio materials · 2019Article
- Novel vinyl-modified RGD conjugated silica nanoparticles based on photo click chemistry forRSC advances · 2019Article
- Gelatin-Based Hydrogels through Homobifunctional Triazolinediones Targeting Tyrosine Residues.Molecules (Basel, Switzerland) · 2019Article
- Influence of theBeilstein journal of organic chemistry · 2019Article
- Multivalent Peptide-Nanoparticle Conjugates for Influenza-Virus Inhibition.Angewandte Chemie (International ed. in English) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the last decades, great efforts have been devoted to design polymers for reducing the toxicity, increasing the absorption, and improving the release profile of drugs. Advantage has been also taken from the inherent multivalency of polymers and dendrimers for the incorporation of diverse functional molecules of interest in targeting and diagnosis. In addition, polymeric hydrogels with the ability to encapsulate drugs and cells have been developed for drug delivery and tissue engineering applications. In the long road to this successful story, pharmaceutical sciences have been accompanied by parallel advances in synthetic methodologies allowing the preparation of precise polymeric materials with enhanced properties. In this context, the introduction of the click concept by Sharpless and coworkers in 2001 focusing the attention on modularity and orthogonality has greatly benefited polymer synthesis, an area where reaction efficiency and product purity are significantly challenged. The purpose of this Expert Review is to discuss the impact of click chemistry in the preparation and functionalization of polymers, dendrimers, and hydrogels of interest in drug delivery.
Indexed as
Identifiers
22274559What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.