ArticlePharmaceutical research2012
Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery.
Article in Pharmaceutical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- A synthetic retinoic acid receptor γ antagonist (7C)-loaded nanoparticle enhances bone morphogenetic protein-induced bone regeneration in a rat spinal fusion model.The spine journal : official journal of the North American Spine Society · 2024Article
- Nanocarrier Design for Dual-Targeted Therapy of In-Stent Restenosis.Pharmaceutics · 2024Article
- Robust Chemical Strategy for Stably Labeling Polyester-Based Nanoparticles with BODIPY Fluorophores.ACS applied polymer materials · 2022Article
- Selective Retinoic Acid Receptor γ Antagonist 7C is a Potent Enhancer of BMP-Induced Ectopic Endochondral Bone Formation.Frontiers in cell and developmental biology · 2022Article
- Experimental Single-Platform Approach to Enhance the Functionalization of Magnetically Targetable Cells.ACS applied bio materials · 2020Article
- Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system.Drug delivery and translational research · 2018Article
- Neoatherosclerosis and Late Thrombosis After Percutaneous Coronary Intervention: Translational Cardiology and Comparative Medicine from Bench to Bedside.The Yale journal of biology and medicine · 2017Review
- Preparation and In Vitro Characterization of Magnetized miR-modified Endothelial Cells.Journal of visualized experiments : JoVE · 2017Article
- Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
- Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Biological magnetic cellular spheroids as building blocks for tissue engineering.Acta biomaterialia · 2014Article
- Superparamagnetic iron oxide nanoparticle-based delivery systems for biotherapeutics.Expert opinion on drug delivery · 2013Review
- Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo.Nanomedicine (London, England) · 2012Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeCells modified with magnetically responsive nanoparticles (MNP) can provide the basis for novel targeted therapeutic strategies. However, improvements are required in the MNP design and cell treatment protocols to provide adequate magnetic properties in balance with acceptable cell viability and function. This study focused on select variables controlling the uptake and cell compatibility of biodegradable polymer-based MNP in cultured endothelial cells.
methodsFluorescent-labeled MNP were formed using magnetite and polylactide as structural components. Their magnetically driven sedimentation and uptake were studied fluorimetrically relative to cell viability in comparison to non-magnetic control conditions. The utility of surface-activated MNP forming affinity complexes with replication-deficient adenovirus (Ad) for transduction achieved concomitantly with magnetic cell loading was examined using the green fluorescent protein reporter.
resultsA high-gradient magnetic field was essential for sedimentation and cell binding of albumin-stabilized MNP, the latter being rate-limiting in the MNP loading process. Cell loading up to 160 pg iron oxide per cell was achievable with cell viability >90%. Magnetically driven uptake of MNP-Ad complexes can provide high levels of transgene expression potentially useful for a combined cell/gene therapy.
conclusionsMagnetically responsive endothelial cells for targeted delivery applications can be obtained rapidly and efficiently using composite biodegradable MNP.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.