ArticleDer Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen2012
[Current TNM system of the UICC/AJCC : the prognostic significance for differentiated thyroid carcinoma].
Article in Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Does every classical type of well-differentiated thyroid cancer have excellent prognosis? A case series and literature review.Cancer management and research · 2019Article
- The prognosis of NX stage differentiated thyroid cancer based on propensity score matching and SEER data.American journal of translational research · 2018Article
- Pigment epithelium-derived factor has a role in the progression of papillary thyroid carcinoma by affecting the HIF1α-VEGF signaling pathway.Oncology letters · 2016Article
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- Clinical features of bone metastasis for differentiated thyroid carcinoma: A study of 21 patients from a Tunisian center.Indian journal of endocrinology and metabolism · 2014Article
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4 authors.
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Abstract
backgroundThe aim of study was an evaluation of prognostic factors of the current TNM version (UICC/AJCC 2009, 7th revision) for differentiated thyroid carcinoma (DTC). PATIENTS AND
methodsA total of 368 patients with DTC (papillary thyroid carcinoma [PTC] n = 269, follicular thyroid carcinoma [FTC] n = 99) were included. Disease-specific survival (DSS) was calculated based on the different TNM stages (mean follow-up 60 ± 37.5 months).
resultsWhen compared to patients with FTC, PTC patients had smaller tumors (diameter 19 mm versus 33 mm), more often lymph node metastases (40.9% versus 9.1%) but less frequent distant metastases (2.6 versus 13.1%) and poorly differentiated variants (PDTC 3.0% versus 8.1%). The 5-year and 10-year DSS for PTC versus FTC were 97.3% versus 91.5% and 96.2% versus 91.5% (p = 0.086), respectively. When comparing different TNM categories between well-differentiated PTC and FTC, no statistically significant differences were found but PDTCs, had a significantly worse DSS.
conclusionsThe current TNM system is a sufficient tool for predicting DSS in well-differentiated PTC. In FTC, the extent of capsular and vascular invasion should also be considered. The implementation of a specific TNM system for PDTC needs to be confirmed in further studies.
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