ArticleNature communications2012
The genetic origin and history of speed in the Thoroughbred racehorse.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 124 citations in OpenAlex.
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- Abundant genetic variation is retained in many laboratory schistosome populations.PLoS pathogens · 2025Article
- Multiomic analysis of different horse breeds reveals that gut microbial butyrate enhances racehorse athletic performance.NPJ biofilms and microbiomes · 2025Article
- Effect of the intrinsic and extrinsic factors on the growth and development of young foals under subtropical conditions of Pakistan.PloS one · 2025Article
- Article
- Genomic-Inbreeding Landscape and Selection Signatures in the Polo Argentino Horse Breed.International journal of molecular sciences · 2024Article
- Analyses of whole-genome sequences from 185 North American Thoroughbred horses, spanning 5 generations.Scientific reports · 2024Article
- Comparative analysis of breeding patterns and reproductive efficiency of mares in subtropical conditions of Pakistan.Veterinary medicine and science · 2024Article
- What Is a Working Equid? Analysis of Current Terminology and a Suggested Definition.Animals : an open access journal from MDPI · 2024Article
- Association between the plasma concentration of melatonin and behavioral temperament in horses.Journal of animal science and technology · 2023Article
- An evaluation of DNA extraction methods on historical and roadkill mammalian specimen.Scientific reports · 2023Article
- Article
- DNA methylation-based profiling of horse archaeological remains for age-at-death and castration.iScience · 2023Article
- Influence of horse demographics, country of training and race distance on the rating of Thoroughbreds.Archives animal breeding · 2023Article
- Common protein-coding variants influence the racing phenotype in galloping racehorse breeds.Communications biology · 2022Article
- Article
- Average stride length and stride rate of Thoroughbreds and Quarter Horses during racing.Translational animal science · 2022Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective breeding for speed in the racehorse has resulted in an unusually high frequency of the C-variant (g.66493737C/T) at the myostatin gene (MSTN) in cohorts of the Thoroughbred horse population that are best suited to sprint racing. Here we show using a combination of molecular- and pedigree-based approaches in 593 horses from 22 Eurasian and North-American horse populations, museum specimens from 12 historically important Thoroughbred stallions (b.1764-1930), 330 elite-performing modern Thoroughbreds and 42 samples from three other equid species that the T-allele was ancestral and there was a single introduction of the C-allele at the foundation stages of the Thoroughbred from a British-native mare. Furthermore, we show that although the C-allele was rare among the celebrated racehorses of the 18th and 19th centuries, it has proliferated recently in the population via the stallion Nearctic (b.1954), the sire of the most influential stallion of modern time, Northern Dancer (b.1961).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.