Evidence map›Paper›PMID 22273078›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2012

Transabdominal evaluation of uterine cervical length during pregnancy fails to identify a substantial number of women with a short cervix.

Edgar Hernandez-Andrade, Roberto Romero, Hyunyoung Ahn, Youssef Hussein, Lami Yeo, Steven J Korzeniewski, Tinnakorn Chaiworapongsa, Sonia S Hassan

Registry-linked trialOpen access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05044143 (Serial Cervical Length Measurements After the 1st Episode of Threatened Preterm Labor to Improve Prediction of Spontaneous Preterm Delivery), which is not on this map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05044143 completednot on this mapstarted 2021, after this paper: background citation

Serial Cervical Length Measurements After the 1st Episode of Threatened Preterm Labor to Improve Prediction of Spontaneous Preterm Delivery: Prospective Cohort Study

TypeobservationalSponsorUniversity of Modena and Reggio EmiliaRan2021 to 2024Enrolled303ConditionsPreterm Labor With Preterm DeliveryArmsMonitoring the length of the uterine cervix using transvaginal ultrasound
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.

  1. Cervical assessment by ultrasound for preventing preterm delivery.The Cochrane database of systematic reviews · 2019
    Pooled it
  2. Cervical assessment by ultrasound for preventing preterm delivery.The Cochrane database of systematic reviews · 2013
    Pooled it
  3. Cervical length assessment using magnetic resonance imaging during pregnancy: correlation and agreement with transvaginal ultrasound.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026
    Article
  4. Article
  5. Preterm Birth: Screening and Prediction.International journal of women's health · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. HIV serostatus, viral load, and midtrimester cervical length in a Zambian prenatal cohort.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2019
    Article
  11. Article
  12. Review
  13. Assessment of Length of Maternal Cervix between 18 and 24 weeks of Gestation in a Low-Risk Brazilian Population.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017
    Article
  14. Article
  15. Reference Ranges for Ultrasonographic Measurements of the Uterine Cervix in Low-Risk Pregnant Women.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2017
    Article
  16. Can Transabdominal Scan Predict a Short Cervix by Transvaginal Scan?Obstetrics and gynecology international · 2017
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Edgar Hernandez-AndradePerinatology Research Branch, NICHD, NIH, DHHS, Detroit, MI 48201, USA.
Roberto Romero
Hyunyoung Ahn
Youssef Hussein
Lami Yeo
Steven J Korzeniewski
Tinnakorn Chaiworapongsa
Sonia S Hassan
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USWayne State University · US

Funding

Prenatal Diagnosis Of Congenital AnomaliesZIAHD002401 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI ROMERO, ROBERTO · 2009 to 2025
$81.1M
Intramural NIH HHS ZIA HD002401
6 · The paper itself

Abstract

objectiveTo assess the diagnostic performance of transabdominal sonographic measurement of cervical length in identifying patients with a short cervix.

methodsCervical length was measured in 220 pregnant women using transabdominal and transvaginal ultrasound (US). Reproducibility and agreement between and within both methods were assessed. The diagnostic accuracy of transabdominal US for identifying cases with a cervical length <25 mm was evaluated.

resultsTwenty-one out of 220 cases (9.5%) had a cervical length <25 mm by transvaginal US. Only 43% (n = 9) of patients with a short cervix were correctly identified by transabdominal US. In patients with a cervical length of <25 mm by transvaginal US, transabdominal measurement of the cervix overestimated this parameter by an average of 8 mm (95% LOAs, -26.4 to 10.5 mm). Among women without a short cervix, transabdominal US underestimated cervical length on average (LOA) by 1.1 mm (95% LOAs, -11.0 to 13.2 mm). Transvaginal US was also more reproducible (intraclass correlation coefficient: (ICC) (0.96; 95% CI, 0.94 to 0.97) based on comparisons between 2D images and immediately acquired 3D volume datasets relative to transabdominal US (ICC: 0.71; 95% CI, 0.57 to 0.84). Transvaginal US detected 13 cases with funneling and six cases with sludge whereas only three cases of funneling and one of sludge were detected by transabdominal US.

conclusionTransabdominal measurement overestimated cervical LOA by 8 mm among women with a short cervix and resulted in the underdiagnosis of 57% of cases.

Indexed as

AbdomenAdolescentAdultCervix UteriDiagnostic ErrorsFalse Negative ReactionsFemaleHumansObstetric Labor, PrematurePregnancyPregnancy ComplicationsReproducibility of ResultsUltrasonography, PrenatalVaginaYoung Adult

Identifiers

PMID22273078
PMCPMC3422449
OpenAlexW2022881990

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.