ArticleBMC microbiology2012
Opposing roles of σB and σB-controlled SpoVG in the global regulation of esxA in Staphylococcus aureus.
Article in BMC microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Type VIIb secretion systems in Lactobacillales: insights from streptococci and enterococci.Journal of bacteriology · 2026Review
- Stage V sporulation protein G as a global regulator of biofilm formation and virulence in Staphylococcus species: molecular mechanisms and therapeutic potential.World journal of microbiology & biotechnology · 2026Review
- Article
- High-throughput functional analysis provides novel insight into type VII secretion inOpen biology · 2024Article
- GlutamateJournal of bacteriology · 2024Article
- Interbacterial competition mediated by the type VIIb secretion system.Microbiology (Reading, England) · 2023Review
- Quantitative analyses of interactions between SpoVG and RNA/DNA.Biochemical and biophysical research communications · 2023Article
- Quantitative analyses of interactions between SpoVG and RNA/DNA.bioRxiv : the preprint server for biology · 2023Article
- RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression.Nature communications · 2022Article
- Protein Elicitor EsxA Induces Resistance to Seedling Blight and PR Genes Differential Transcription in Rice.Rice (New York, N.Y.) · 2021Article
- The Type VII Secretion System ofAnnual review of microbiology · 2021Article
- Cloning and expression of the EsxA gene and the growth-promoting effects of the encoded protein on rice seedlings.AMB Express · 2021Article
- Activation of a bacterial killing machine.PLoS genetics · 2021Article
- The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA.Molecular microbiology · 2020Article
- Protein Export into and across the Atypical Diderm Cell Envelope of Mycobacteria.Microbiology spectrum · 2019Review
- Relationship Between Quorum Sensing and Secretion Systems.Frontiers in microbiology · 2019Review
- Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390.Microbiology (Reading, England) · 2017Article
- Host-derived fatty acids activate type VII secretion inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection.Virulence · 2017Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe production of virulence factors in Staphylococcus aureus is tightly controlled by a complex web of interacting regulators. EsxA is one of the virulence factors that are excreted by the specialized, type VII-like Ess secretion system of S. aureus. The esxA gene is part of the σB-dependent SpoVG subregulon. However, the mode of action of SpoVG and its impact on other global regulators acting on esxA transcription is as yet unknown.
resultsWe demonstrate that the transcription of esxA is controlled by a regulatory cascade involving downstream σB-dependent regulatory elements, including the staphylococcal accessory regulator SarA, the ArlRS two-component system and SpoVG. The esxA gene, preceding the ess gene cluster, was shown to form a monocistronic transcript that is driven by a σA promoter, whereas a putative σB promoter identified upstream of the σA promoter was shown to be inactive. Transcription of esxA was strongly upregulated upon either sarA or sigB inactivation, but decreased in agr, arlR and spoVG single mutants, suggesting that agr, ArlR and SpoVG are able to increase esxA transcription and relieve the repressing effect of the σB-controlled SarA on esxA.
conclusionSpoVG is a σB-dependent element that fine-tunes the expression of esxA by counteracting the σB-induced repressing activity of the transcriptional regulator SarA and activates esxA transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.