ArticlePloS one2012
Encoding odorant identity by spiking packets of rate-invariant neurons in awake mice.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Odor identity decoding by mitral/tufted cells in the olfactory bulb from large-scale pooled datasets.iScience · 2026Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- NEGR1 Modulates Mouse Affective Discrimination by Regulating Adult Olfactory Neurogenesis.Biological psychiatry global open science · 2024Article
- Packet information encoding in a cerebellum-like circuit.PloS one · 2024Article
- Stimulus-Induced Theta-Band LFP Oscillations Format Neuronal Representations of Social Chemosignals in the Mouse Accessory Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Long-range GABAergic projections contribute to cortical feedback control of sensory processing.Nature communications · 2022Article
- Coupling of Mouse Olfactory Bulb Projection Neurons to Fluctuating Odor Pulses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Odor coding in piriform cortex: mechanistic insights into distributed coding.Current opinion in neurobiology · 2020Review
- Learning improves decoding of odor identity with phase-referenced oscillations in the olfactory bulb.eLife · 2020Article
- Complex neural representation of odour information in the olfactory bulb.Acta physiologica (Oxford, England) · 2020Review
- Similarity and Strength of Glomerular Odor Representations Define a Neural Metric of Sniff-Invariant Discrimination Time.Cell reports · 2019Article
- Efficient calculation of heterogeneous non-equilibrium statistics in coupled firing-rate models.Journal of mathematical neuroscience · 2019Article
- Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia.Nature neuroscience · 2018Article
- Temporal Response Properties of Accessory Olfactory Bulb Neurons: Limitations and Opportunities for Decoding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation.Frontiers in cellular neuroscience · 2018Article
- A theoretical framework for analyzing coupled neuronal networks: Application to the olfactory system.PLoS computational biology · 2017Article
- Context- and Output Layer-Dependent Long-Term Ensemble Plasticity in a Sensory Circuit.Neuron · 2017Article
- Behavioral Status Influences the Dependence of Odorant-Induced Change in Firing on Prestimulus Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A probabilistic approach to demixing odors.Nature neuroscience · 2017Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundHow do neural networks encode sensory information? Following sensory stimulation, neural coding is commonly assumed to be based on neurons changing their firing rate. In contrast, both theoretical works and experiments in several sensory systems showed that neurons could encode information as coordinated cell assemblies by adjusting their spike timing and without changing their firing rate. Nevertheless, in the olfactory system, there is little experimental evidence supporting such model. METHODOLOGY/PRINCIPAL
findingsTo study these issues, we implanted tetrodes in the olfactory bulb of awake mice to record the odorant-evoked activity of mitral/tufted (M/T) cells. We showed that following odorant presentation, most M/T neurons do not significantly change their firing rate over a breathing cycle but rather respond to odorant stimulation by redistributing their firing activity within respiratory cycles. In addition, we showed that sensory information can be encoded by cell assemblies composed of such neurons, thus supporting the idea that coordinated populations of globally rate-invariant neurons could be efficiently used to convey information about the odorant identity. We showed that different coding schemes can convey high amount of odorant information for specific read-out time window. Finally we showed that the optimal readout time window corresponds to the duration of gamma oscillations cycles.
conclusionWe propose that odorant can be encoded by population of cells that exhibit fine temporal tuning of spiking activity while displaying weak or no firing rate change. These cell assemblies may transfer sensory information in spiking packets sequence using the gamma oscillations as a clock. This would allow the system to reach a tradeoff between rapid and accurate odorant discrimination.
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