ArticlePloS one2012
The mechanism of antifungal action of essential oil from dill (Anethum graveolens L.) on Aspergillus flavus.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
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Who cites it
98 citing papers in PubMed, 392 citations in OpenAlex.
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- Mechanistic and applied insights into antifungal action of essential oils and phytochemical extracts againstFrontiers in microbiology · 2026Article
- The anti-coronaviral activity of singular and mixed formulation of dill essential oil (Anethum graveolens L.) and tannic acid (Quercus infectoria).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Bacillus thuringiensis G-5 efficiently suppresses Codonopsis pilosula postharvest diseases by generating antifungal volatile organic compounds.Antonie van Leeuwenhoek · 2025Article
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- Synergistic Antifungal Properties, Chemical Composition, and Frontier Molecular Orbital Analysis of Essential Oils from Lemongrass, Kaffir Lime, Lime, Dill, and Shatavari AgainstInternational journal of molecular sciences · 2025Article
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- Unraveling the antifungal and aflatoxin B1 inhibitory efficacy of nano-encapsulated caraway essential oil based on molecular docking of major components.Scientific reports · 2025Article
- Enhancing dispersion stability of nano zinc oxide with rhamnolipids and evaluating antibacterial activity against harmful corn fungi.Frontiers in microbiology · 2025Article
- The Role of Essential Oils on Sleep Quality and Other Sleep-related Issues: Evidence from Clinical Trials.Mini reviews in medicinal chemistry · 2025Review
- Unveiling novel insights: geraniol's enhanced anti-candida efficacy and mechanistic innovations against multidrug-resistant candida strains.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Antifungal Effect of Oregano Essential Oil AgainstJournal of fungi (Basel, Switzerland) · 2024Article
- Cestrum tomentosum L.f. Extracts against Colletotrichum scovillei by Altering Cell Membrane Permeability and Inducing ROS Accumulation.The plant pathology journal · 2024Article
- D-Limonene InhibitsMolecules (Basel, Switzerland) · 2024Article
38 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essential oil extracted from the seeds of dill (Anethum graveolens L.) was demonstrated in this study as a potential source of an eco-friendly antifungal agent. To elucidate the mechanism of the antifungal action further, the effect of the essential oil on the plasma membrane and mitochondria of Aspergillus flavus was investigated. The lesion in the plasma membrane was detected through flow cytometry and further verified through the inhibition of ergosterol synthesis. The essential oil caused morphological changes in the cells of A. flavus and a reduction in the ergosterol quantity. Moreover, mitochondrial membrane potential (MMP), acidification of external medium, and mitochondrial ATPase and dehydrogenase activities were detected. The reactive oxygen species (ROS) accumulation was also examined through fluorometric assay. Exposure to dill oil resulted in an elevation of MMP, and in the suppression of the glucose-induced decrease in external pH at 4 µl/ml. Decreased ATPase and dehydrogenase activities in A. flavus cells were also observed in a dose-dependent manner. The above dysfunctions of the mitochondria caused ROS accumulation in A. flavus. A reduction in cell viability was prevented through the addition of L-cysteine, which indicates that ROS is an important mediator of the antifungal action of dill oil. In summary, the antifungal activity of dill oil results from its ability to disrupt the permeability barrier of the plasma membrane and from the mitochondrial dysfunction-induced ROS accumulation in A. flavus.
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