Evidence map›Paper›PMID 22272129›Full record

ReviewInternational journal of molecular sciences2011

Hormonal influence on coenzyme Q(10) levels in blood plasma.

Antonio Mancini, Roberto Festa, Sebastiano Raimondo, Alfredo Pontecorvi, Gian Paolo Littarru

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. CoQJournal of clinical medicine · 2020
    Article
  10. Visfatin, PON-1 Levels in Iraqi Hyperthyroidism Patient's with Dyslipidemia.Indian journal of clinical biochemistry : IJCB · 2019
    Article
  11. Effect of Ubiquinol on Serum Reproductive Hormones of Amenorrhic Patients.Indian journal of clinical biochemistry : IJCB · 2016
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Antonio ManciniDepartment of Internal Medicine, Division of Endocrinology, Catholic University of the Sacred Heart, Largo Gemelli, 1-00168 Rome, Italy. mancini.giac@mclink.it
Roberto Festa
Sebastiano Raimondo
Alfredo Pontecorvi
Gian Paolo Littarru
Università Cattolica del Sacro Cuore · ITMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coenzyme Q(10) (CoQ(10)), also known as ubiquinone for its presence in all body cells, is an essential part of the cell energy-producing system. However, it is also a powerful lipophilic antioxidant protecting lipoproteins and cell membranes. Due to these two actions, CoQ(10) is commonly used in clinical practice in chronic heart failure, male infertility, and neurodegenerative disease. However, it is also taken as an anti-aging substance by healthy people aiming for long-term neuroprotection and by sportsmen to improve endurance. Many hormones are known to be involved in body energy regulation, in terms of production, consumption and dissipation, and their influence on CoQ(10) body content or blood values may represent an important pathophysiological mechanism. We summarize the main findings of the literature about the link between hormonal systems and circulating CoQ(10) levels. In particular the role of thyroid hormones, directly involved in the regulation of energy homeostasis, is discussed. There is also a link with gonadal and adrenal hormones, partially due to the common biosynthetic pathway with CoQ(10), but also to the increased oxidative stress found in hypogonadism and hypoadrenalism.

Indexed as

Adrenal Cortex HormonesEndocrine System DiseasesGonadal HormonesHumansThyroid HormonesUbiquinoneAdrenal Cortex Hormonescoenzyme Q10Gonadal HormonesThyroid HormonesUbiquinoneantioxidantscoenzyme Q10oxidative stresspituitarythyroid

Identifiers

PMID22272129
PMCPMC3257126
OpenAlexW2122887343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.