ArticleJournal of toxicologic pathology2011
Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis.
Article in Journal of toxicologic pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Investigation of Leptin G19A polymorphism with bladder cancer risk: A case-control study.Journal of clinical laboratory analysis · 2020Article
- The role of adipocytokines and their receptors in bladder cancer: expression of adiponectin or leptin is an independent prognosticator.American journal of translational research · 2020Article
- The association of BMI with risk of recurrence and progression in patients with non-muscle-invasive bladder cancer.Translational andrology and urology · 2018Article
- Vitamin D, obesity and leptin in relation to bladder cancer incidence and survival: prospective protocol study.BMJ open · 2018Article
- Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis.International journal of molecular sciences · 2017Article
- Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay.Journal of toxicologic pathology · 2017Article
- Article
- Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes.Current diabetes reviews · 2014Review
- Detection of γ-H2AX, a Biomarker for DNA Double-strand Breaks, in Urinary Bladders of N -Butyl- N -(4-Hydroxybutyl)-Nitrosamine-Treated Rats.Journal of toxicologic pathology · 2013Article
- Obesity, independent of p53 gene dosage, promotes mammary tumor progression and upregulates the p53 regulator microRNA-504.PloS one · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
In the present study, modifying effects of diabetes on carcinogenesis induced in type 2 diabetes mellitus model Zucker diabetic fatty (ZDF) rats were investigated using a multiorgan carcinogenesis bioassay. Our re sults demonstrated enhancement of urinary bladder, colon and liver carcinogenesis in ZDF rats treated with five types of carcinogens (DMBDD). Elevated insulin and leptin and decreased adiponectin levels in the serum may be responsible for the high susceptibility of type 2 diabetes mellitus model rats to carcinogenesis in these organs. Possible mechanisms of increased susceptibility of diabetic rats to bladder carcinogenesis could be activation of the PI3K pathway and suppression of p53 in the urothelium in consequence of the above serum protein alterations.
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