ArticleJournal of toxicologic pathology2010
Morphological and Biochemical Changes During Aging and Photoaging of the Skin of C57BL/6J Mice.
Article in Journal of toxicologic pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of European Bilberry Extract on Skin Aging Associated with Consumption of a High Temperature Roasted Diet in Rats.Nutrients · 2026Article
- Quercetin Emulsion Ameliorates UVA-Induced Skin via Modulation of NRF2/NF-κB Signaling Pathways.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Multispectral Laser-Scanning Photoacoustic Microscopy With SRS-Generated Wavelengths for Skin Chromophore Characterization.Journal of biophotonics · 2026Article
- METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an mAging cell · 2024Article
- Review
- Antioxidant and Antiaging Properties of Agar Obtained from Brown SeaweedEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Skin aging as a mechanical phenomenon: The main weak links.Nutrition and healthy aging · 2018Article
- Activation of Nrf2 Reduces UVA-Mediated MMP-1 Upregulation via MAPK/AP-1 Signaling Cascades: The Photoprotective Effects of Sulforaphane and Hispidulin.The Journal of pharmacology and experimental therapeutics · 2017Article
- Role of adipose tissue in facial aging.Clinical interventions in aging · 2017Review
- Interfacial Adipose Tissue in Systemic Sclerosis.Current rheumatology reports · 2017Review
- Skin aging: are adipocytes the next target?Aging · 2016Review
- 11β-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects.The Journal of clinical investigation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The differences between the dorsal skin of 11- and 16-week-old C57BL/6J mice were examined morphologically and biochemically. The dermis of the 16-week-old mice was thinner than that of the 11-week-old mice due to decreases in the amounts of soluble collagen and elastin. Next, the changes in dorsal skin exposed to UVA irradiation for 8 weeks (576 J/cm(2)) were examined in 3 (younger)- and 8 (older)-week-old C57BL/6J mice. The thickness of the dermis was not significantly different between the UVA-irradiated and control mice in either the younger or older group. The increase in the amount of collagen was related to the increase in the level of soluble collagen in the younger mice. In contrast, it was related to the increase in the level of insoluble collagen in the older mice. In the UVA-irradiated older mice, the activity of the latent form of MMP-13 was significantly higher than that in the control mice. These results suggest that aging and UVA-induced photoaging in the skin are histologically and biochemically different phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.