ArticleJournal of lipid research2012
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes.
Article in Journal of lipid research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 224 papers.
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Who cites it
224 citing papers in PubMed, 459 citations in OpenAlex.
- Peripheral Neuropathy in Metabolic Stress.International journal of molecular sciences · 2026Review
- Single-nucleus analysis of human white adipose tissue reveals adipocyte subsets with distinct metabolic profiles.Nature communications · 2026Article
- The regulatory effects of growth hormone on adipose tissue at physiological and pathological levels and its relationship with obesity.International journal of obesity (2005) · 2026Review
- An Unexpected Journey Into Brown Fat Research for Metabolic Health: The 2025 Outstanding Scientific Achievement Award Lecture.Diabetes · 2025Article
- Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression.Lipids in health and disease · 2025Article
- Intermittent Cold Exposure Induces Distinct Proteomic Signatures in White Adipose Tissue of Mice.International journal of molecular sciences · 2025Article
- Phenotypic and developmental dissection of an instance of the island rule.Evolution; international journal of organic evolution · 2025Article
- Emerging Insights into Brown Adipose Tissue Crosstalk With Pancreatic β-Cells in Metabolic Regulation.Endocrinology · 2025Review
- Adipocyte CLDN5 promotes thermogenesis and energy expenditure through regulation of IL10 expression.Nature communications · 2025Article
- Ingesting Nuts Can Regulate Adipokines Expression in Individuals Living with Overweight and Obesity: A Narrative Review of What Is Known So Far.Nutrients · 2025Review
- Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine AMolecular medicine (Cambridge, Mass.) · 2025Article
- Phenotypic and Developmental Dissection of an Instance of the Island Rule.bioRxiv : the preprint server for biology · 2025Article
- Thermogenic Adipocytes Promote M2 Macrophage Polarization through CNNM4-Mediated Mg Secretion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Hypoxia-inducible factor-1α-deficient adipose-tissue macrophages produce the heat to mediate lipolysis of white adipose tissue through uncoupling protein-1.Laboratory animal research · 2024Article
- Two Regions with Different Expression of Lipogenic Enzymes in Rats' Posterior Subcutaneous Fat Depot.International journal of molecular sciences · 2024Article
- Brown AlgaeMarine drugs · 2024Article
- Is Propolis a Potential Anti-Obesogenic Agent for Obesity?Current nutrition reports · 2024Review
- White adipocyte dysfunction and obesity-associated pathologies in humans.Nature reviews. Molecular cell biology · 2024Review
- Article
- Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity.Journal of clinical medicine · 2024Review
164 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures. Most of the fat tissue was contained in depots with discrete anatomical features, and most depots contained both white and brown adipocytes. Quantitative analysis showed that cold acclimation induced an increase in brown adipocytes and an almost equal reduction in white adipocytes; however, there were no significant differences in total adipocyte count or any signs of apoptosis or mitosis, in line with the hypothesis of the direct transformation of white into brown adipocytes. The brown adipocyte increase was accompanied by enhanced density of noradrenergic parenchymal nerve fibers, with a significant correlation between the density of these fibers and the number of brown adipocytes. Comparison with data from obesity-resistant Sv129 mice disclosed a significantly different brown adipocyte content in C57BL/6J mice, suggesting that this feature could underpin the propensity of the latter strain to develop obesity. However, the greater C57BL/6J browning capacity can hopefully be harnessed to curb obesity and type 2 diabetes in patients with constitutively low amounts of brown adipose tissue.
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