ArticleProtein & cell2012
Rapid conversion of human ESCs into mouse ESC-like pluripotent state by optimizing culture conditions.
Article in Protein & cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Conversion between porcine naïve-like and primed ESCs and specific pluripotency marker identification.In vitro cellular & developmental biology. Animal · 2020Article
- Two decades of embryonic stem cells: a historical overview.Human reproduction open · 2019Article
- CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells.Scientific reports · 2017Article
- Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells.Scientific reports · 2015Article
- Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation.Cellular reprogramming · 2015Article
- Derivation and characterization of human embryonic stem cells on human amnion epithelial cells.Scientific reports · 2015Article
- Efficient generation of mouse ESCs-like pig induced pluripotent stem cells.Protein & cell · 2014Article
- Article
- RNA-based tools for nuclear reprogramming and lineage-conversion: towards clinical applications.Journal of cardiovascular translational research · 2013Review
- Tbx3 and Nr5α2 play important roles in pig pluripotent stem cells.Stem cell reviews and reports · 2013Article
- Generation of induced pluripotent stem cells with high efficiency from human umbilical cord blood mononuclear cells.Genomics, proteomics & bioinformatics · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pluripotent state between human and mouse embryonic stem cells is different. Pluripotent state of human embryonic stem cells (ESCs) is believed to be primed and is similar with that of mouse epiblast stem cells (EpiSCs), which is different from the naïve state of mouse ESCs. Human ESCs could be converted into a naïve state through exogenous expression of defined transcription factors (Hanna et al., 2010). Here we report a rapid conversion of human ESCs to mouse ESC-like naïve states only by modifying the culture conditions. These converted human ESCs, which we called mhESCs (mouse ESC-like human ESCs), have normal karyotype, allow single cell passage, exhibit domed morphology like mouse ESCs and express some pluripotent markers similar with mouse ESCs. Thus the rapid conversion established a naïve pluripotency in human ESCs like mouse ESCs, and provided a new model to study the regulation of pluripotency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.