ArticleBlood2012
A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Anti-VEGF therapy improves EGFR-vIII-CAR-T cell delivery and efficacy in syngeneic glioblastoma models in mice.Journal for immunotherapy of cancer · 2023Article
- Light sheet fluorescence microscopy for quantitative three-dimensional imaging of vascular remodelling.Cardiovascular research · 2021Article
- Developing a xenograft model of human vasculature in the mouse ear pinna.Scientific reports · 2020Article
- Article
- Non-Invasive Multiphoton Imaging of Islets Transplanted Into the Pinna of the NOD Mouse Ear Reveals the Immediate Effect of Anti-CD3 Treatment in Autoimmune Diabetes.Frontiers in immunology · 2018Article
- A Novel Cellular Pathway of Antigen Presentation and CD4 T Cell ActivationFrontiers in immunology · 2018Article
- Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.Nature communications · 2017Article
- SipA Activation of Caspase-3 Is a Decisive Mediator of Host Cell Survival at Early Stages of Salmonella enterica Serovar Typhimurium Infection.Infection and immunity · 2017Article
- Sphingosine-1-Phosphate Promotes the Persistence of Activated CD4 T Cells in Inflamed Sites.Frontiers in immunology · 2017Article
- Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity.NPJ vaccines · 2017Article
- Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment.Journal of immunology research · 2016Review
- Cellular imaging in rheumatic diseases.Nature reviews. Rheumatology · 2015Review
- Recellularization potential assessment of Wharton's Jelly-derived endothelial progenitor cells using a human fetal vascular tissue model.In vitro cellular & developmental biology. Animal · 2014Article
- Using lymph node transplantation as an approach to image cellular interactions between the skin and draining lymph nodes during parasitic infections.Parasitology international · 2014Review
- Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules.BioMed research international · 2014Article
- Lymphatic vessel function in head and neck inflammation.Lymphatic research and biology · 2013Article
- Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin.Intravital · 2013Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses. Until now, invasive surgery has been required for microscopic access to lymph nodes (LNs), making repeated imaging of the same animal impractical and potentially affecting lymphocyte behavior. To allow longitudinal in vivo imaging, we conceived the novel approach of transplanting LNs into the mouse ear pinna. Transplanted LNs maintain the structural and cellular organization of conventional secondary lymphoid organs. They participate in lymphocyte recirculation and exhibit the capacity to receive and respond to local antigenic challenge. The same LN could be repeatedly imaged through time without the requirement for surgical exposure, and the dynamic behavior of the cells within the transplanted LN could be characterized. Crucially, the use of blood vessels as fiducial markers also allowed precise re-registration of the same regions for longitudinal imaging. Thus, we provide the first demonstration of a method for repeated, noninvasive, in vivo imaging of lymphocyte behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.