ArticleMedical oncology (Northwood, London, England)2012
Single-nucleotide polymorphisms of integrins are associated with the risk and lymph node metastasis of oral squamous cell carcinoma.
Article in Medical oncology (Northwood, London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Association between polymorphisms of microRNA-binding sites in integrin genes and gastric cancer in Chinese Han population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Causal inference of gene regulation with subnetwork assembly from genetical genomics data.Nucleic acids research · 2014Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integrins mediate cell-extracellular matrix (ECM) interaction and play a critical role in cell proliferation, migration, survival, and invasion. Polymorphisms of the Integrin gene can alter integrin protein expression, which may further increase the risk of malignancies or cause poor clinical outcomes. The aim of this study was to investigate the potential associations of single-nucleotide polymorphisms (SNPs) of the integrin gene with the susceptibility and clinicopathologic parameters of oral squamous cell carcinoma (OSCC). Two hundred patients with OSCC and 200 healthy volunteers were recruited. Five SNPs of Integrin genes were analyzed by polymerase chain reaction-restriction fragment length polymorphism genotyping. Their correlations with OSCC risk and clinical tumor characteristics were evaluated. The AT genotype of rs3809865 and GC genotype of rs1190271 increased the risk of OSCC by 2.1-fold (95% confidence interval 1.323-3.829, P=0.004) and 2.85-fold (95% confidence interval 1.583-5.138, P<0.01), respectively. Cases with AT genotype of rs3809865 and GC genotype of rs11902171 were prone to have regional lymph nodes metastasis (P<0.01). The SNPs of rs3809865 and rs1190271 might contribute to the prediction of susceptibility and lymph node metastasis of OSCC, which should be thought as a diagnostic marker and a potential therapeutic target.
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