ReviewInternal and emergency medicine2012
Kounis syndrome (allergic acute coronary syndrome): different views in allergologic and cardiologic literature.
Review in Internal and emergency medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 61 citations in OpenAlex.
- Systemic inflammation increases mast cell numbers in coronary arteries in patients who died from myocardial infarction.Journal of molecular and cellular cardiology plus · 2026Article
- Kounis Syndrome Features in Special Populations.Medical sciences (Basel, Switzerland) · 2026Review
- Kounis Syndrome in Cardiac Surgery: Pathophysiology, Antimicrobial Triggers, and Perioperative Recognition and Management.Medical sciences (Basel, Switzerland) · 2026Review
- Article
- Cardiovascular manifestations in mast cell activation disease: key insights for cardiologists and angiologists.Frontiers in cardiovascular medicine · 2025Review
- Case Report: Kounis syndrome due to cryptopteran bite.Frontiers in cardiovascular medicine · 2024Article
- Resuscitation of a case of allergy, infarction, and ventricular fibrillation: Kounis syndrome type II and literature review.American journal of translational research · 2024Article
- Kounis syndrome in a patient with multivessel coronary artery disease and DRESS.Clinical case reports · 2023Article
- Allergic myocardial infarction (type III Kounis syndrome) secondary to mushroom ingestion: An unusual cause of very late stent thrombosis of saphenous venous graft and refractory no-reflow phenomenon.Journal of cardiology cases · 2022Article
- A Case of Kounis Syndrome Presenting as Coronary Artery Spasm Associated with Acetaminophen Infusion.The American journal of case reports · 2021Article
- Cardiac complications in a patient affected by systemic mastocytosis and primitive myelofibrosis: A case report.Clinical case reports · 2021Article
- Kounis Syndrome Secondary to Medicine-Induced Hypersensitivity.Case reports in medicine · 2021Article
- Biphasic anaphylaxis manifested as type I Kounis syndrome induced by ingestion of raw fish gallbladder: A case report.World journal of emergency medicine · 2021Article
- Kounis syndrome due to hirudotherapy (leech therapy) in emergency department; a case report.Turkish journal of emergency medicine · 2018Article
- Kounis syndrome induced by oral intake of aspirin: case report and literature review.The Pan African medical journal · 2018Review
- Ibuprofen-induced Kounis syndrome with diffuse ST segment depression and atrial fibrillation.Anatolian journal of cardiology · 2017Article
- Article
- Hypersensitivity myocarditis or Kounis syndrome?Internal and emergency medicine · 2014Article
- Mastocytosis presenting as cardiac emergency.Internal and emergency medicine · 2013Article
- Tako-Tsubo cardiomyopathy or allergic acute coronary syndrome: that is the question.Internal and emergency medicine · 2013Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical picture of myocardial ischemia accompanying allergic reactions is defined in the cardiologic literature as Kounis syndrome (KS) or allergic angina/myocardial infarction. In PubMed, a search for "Kounis syndrome", "allergic angina" or "allergic myocardial infarction" retrieves more than 100 results (among case reports, case series and reviews), most of which are published in cardiology/internal medicine/emergency medicine journals. In allergologic literature, heart involvement during anaphylactic reactions is well documented, but Kounis syndrome is hardly mentioned. Single case reports and small case series of angina triggered by allergic reactions have been reported for many years, and involvement of histamine and others mast cell mediators in the pathogenesis of coronary spasm has long been hypothesized, but the existence of an allergic acute coronary syndrome (ACS) is still questioned in the allergologic scientific community. Putative mechanisms of an allergic acute coronary syndrome include coronary spasm or heart tissue-resident mast cell activation (precipitating coronary spasm or inducing plaque rupture and coronary or stent thrombosis) due to systemic increase of allergic mediators, or heart tissue-resident mast cell activation by local stimuli. Indeed, the pathogenic mechanism of an ACS after an allergic insult might be related to direct effects of mast cell mediators on the myocardium and the atherosclerotic plaque, or to exacerbation of preexisting disease by the hemodynamic stress of the acute allergic/anaphylactic reaction. Which of these mechanisms is most important is still unclear, and this review outlines current views in the cardiologic and allergologic literature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.