ArticlePediatric nephrology (Berlin, Germany)2012
Henoch-Schönlein purpura with hypocomplementemia.
Article in Pediatric nephrology (Berlin, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- ANCA-associated vasculitis with protein-losing enteropathy is characterized by hypocomplementemia.Rheumatology international · 2022Pooled it
- Pitfalls in complement analysis: A systematic literature review of assessing complement activation.Frontiers in immunology · 2022Pooled it
- Demographic, Clinical, and Laboratory Characteristics of Pediatric IgA Vasculitis: A Retrospective Five-Year Single-Center Experience.Journal of clinical medicine · 2026Article
- Article
- Clinical review of adult Henoch-Schönlein purpura and analysis of predictors related to gastrointestinal involvement.Frontiers in immunology · 2025Article
- Immunological Features of Children with Gastrointestinal Bleeding Due to Henoch-Schönlein Purpura.Pediatric health, medicine and therapeutics · 2024Article
- [Immunoglobulin A vasculitis (IgAV)].Zeitschrift fur Rheumatologie · 2023Article
- Classic IgA-Vasculitis With Nephrotic Range Proteinuria - Rare Presentation in an Adult.Journal of community hospital internal medicine perspectives · 2023Article
- Article
- Hypocomplementemic Atypical IgA Vasculitis: A Case Report.Frontiers in pediatrics · 2022Article
- IgA vasculitis update: Epidemiology, pathogenesis, and biomarkers.Frontiers in immunology · 2022Review
- A retrospective study on the characteristics of renal pathological grades in HSPN children with mild to moderate proteinuria.Frontiers in pediatrics · 2022Article
- IgA Vasculitis in Adults: a Rare yet Challenging Disease.Current rheumatology reports · 2021Review
- Streptococcal infection in childhood Henoch-Schönlein purpura: a 5-year retrospective study from a single tertiary medical center in China, 2015-2019.Pediatric rheumatology online journal · 2021Article
- [Dermatomyositis combined with IgA vasculitis: A case report].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Review
- Lupus anticoagulant-hypoprothrombinemia syndrome and immunoglobulin-A vasculitis: a report of Japanese sibling cases and review of the literature.Rheumatology international · 2019Review
- Children with Henoch-Schönlein purpura with low complement levels: follow-up for >6 years.Pediatric nephrology (Berlin, Germany) · 2017Article
- A Case of Henoch-Schonlein Purpura Associated with Rotavirus Infection in an Elderly Asian Male and Review of the Literature.The American journal of case reports · 2017Review
- Henoch Schonlein Purpura as a Cause of Renal Failure in an Adult.Case reports in medicine · 2016Article
- 24h Urinary Protein Levels and Urine Protein/Creatinine Ratios Could Probably Forecast the Pathological Classification of HSPN.PloS one · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormalities of the complement system in Henoch-Schönlein purpura (HSP) have been reported, but how this abnormality in the complement system impacts on the prognosis of HSP remains unknown.
methodsWe retrospectively studied patients hospitalized for HSP in the Children's Hospital Affiliated to Soochow University between October 2010 and May 2011. Patients with HSP and hypocomplementemia were the cases, and those without hypocomplementemia were the HSP controls. Another group of children (n = 50) with upper respiratory tract infections, but without HSP acted as negative controls.
resultsA total number of 338 HSP patients were included in this study (n = 53 cases, n = 285 controls). In the cases, C3 and C4 levels decreased in 29 patients, C3 was low in 6, and C4 in 18. Complement levels returned to normal within 3 months in all HSP patients except one. Case group patients had higher levels of serum IgG and arthralgia, as well as positive titers of antistreptolysin-O. Rates of abdominal pain, gastrointestinal bleeding, Henoch-Schönlein purpura nephritis (HSPN), and serum IgA and IgM levels were similar in the two HSP groups.
conclusionHypocomplementemia associated with HSP is a transient phenomenon. The incidence of significant sequelae such as HSPN between patients with and without hypocomplementemia does not differ.
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