ArticleHippocampus2012
Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning.
Article in Hippocampus, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 65 citations in OpenAlex.
- Review
- Aniracetam Ameliorates Attention Deficit Hyperactivity Disorder Behavior in Adolescent Mice.eNeuro · 2025Article
- Synaptic acetylcholine induces sharp wave ripples in the basolateral amygdala through nicotinic receptors.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in contextual fear conditioning and extinction after acute and chronic nicotine treatment.Biology of sex differences · 2024Article
- Basal forebrain cholinergic systems as circuits through which traumatic stress disrupts emotional memory regulation.Neuroscience and biobehavioral reviews · 2024Review
- Nicotine-mediated activation of α2 nAChR-expressing OLM cells in developing mouse brains disrupts OLM cell-mediated control of LTP in adolescence.Neurobiology of learning and memory · 2022Article
- Article
- Translational Research in Nicotine Addiction.Cold Spring Harbor perspectives in medicine · 2021Review
- Long-term effects of early postnatal nicotine exposure on cholinergic function in the mouse hippocampal CA1 region.Neurobiology of learning and memory · 2021Article
- Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.Brain structure & function · 2021Article
- Systemic nicotine enhances opioid self-administration and modulates the formation of opioid-associated memories partly through actions within the insular cortex.Scientific reports · 2021Article
- Paternal nicotine enhances fear memory, reduces nicotine administration, and alters hippocampal genetic and neural function in offspring.Addiction biology · 2021Article
- Treadmill exercise ameliorates nicotine withdrawal-induced symptoms.Journal of exercise rehabilitation · 2019Article
- Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Disruption of medial septum and diagonal bands of Broca cholinergic projections to the ventral hippocampus disrupt auditory fear memory.Neurobiology of learning and memory · 2018Article
- Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery.Brain research bulletin · 2018Article
- Differential Effects of Nicotine Exposure on the Hippocampus Across Lifespan.Current neuropharmacology · 2018Review
- Acute nicotine disrupts consolidation of contextual fear extinction and alters long-term memory-associated hippocampal kinase activity.Neurobiology of learning and memory · 2017Article
- Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning.Neuropharmacology · 2017Article
- Nicotine disrupts safety learning by enhancing fear associated with a safety cue via the dorsal hippocampus.Journal of psychopharmacology (Oxford, England) · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity α7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that α7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.