ArticleThe International journal of eating disorders2012
Examining associations between disordered eating and serotonin transporter gene polymorphisms.
Article in The International journal of eating disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- A genetically informed cross-lagged twin study of the longitudinal association between addiction-related behaviors and obesity.Addiction (Abingdon, England) · 2026Article
- Shared Genetic Influences Between Loss-of-Control Eating and Body Mass Index in Adolescent Twins.The International journal of eating disorders · 2024Article
- Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- A Missense Variant inBiomedicines · 2022Article
- Perceived family functioning among adolescents with and without loss of control eating.Eating behaviors · 2019Article
- Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans.British journal of pharmacology · 2014Review
- Colorado Twin Registry: an update.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2013Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveThe serotonin system has been implicated in mood and appetite regulation, and the serotonin transporter gene (SLC6A4) is a commonly studied candidate gene for eating pathology. However, most studies have focused on a single polymorphism (5-HTTLPR) in SLC6A4; little research has utilized multiple single nucleotide polymorphisms (SNPs) to investigate associations between SLC6A4 and eating pathology more comprehensively.
methodFamily-based association tests were conducted for seven polymorphisms in or near SLC6A4, using families from the Colorado Center for Antisocial Drug Dependence. Data were available for 135 families, with phenotypic data available for female twins and female nontwin siblings. Seven items assessed two disordered eating characteristics: weight and shape concerns and behaviors (WSCB) and binge eating (BE).
resultsNo significant associations were found between any genetic variant and the two disordered eating characteristics. DISCUSSION: This study suggests that utilizing polymorphisms in and near SLC6A4, including 5-HTTLPR, may not be useful in identifying genetic risk factors for disordered eating.
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