On the evidence for ESR1 amplification in breast cancer.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Estrogen Receptor Alpha Gene Amplification Is an Independent Predictor of Long-Term Outcome in Postmenopausal Patients with Endocrine-Responsive Early Breast Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
   Trial
2. Molecular Mechanisms and Therapeutic Strategies to Overcome Resistance to Endocrine Therapy and CDK4/6 Inhibitors in Advanced ER+/HER2- Breast Cancer.International journal of molecular sciences · 2025
   Review
3. Novel Treatment Strategies for Hormone Receptor (HR)-Positive, HER2-Negative Metastatic Breast Cancer.Journal of clinical medicine · 2024
   Review
4. Enhancer methylation dynamics contribute to cancer plasticity and patient mortality.Genome research · 2016
   Article
5. Estrogen receptor alpha gene amplification in breast cancer: 25 years of debate.World journal of clinical oncology · 2016
   Review
6. Mechanisms of aromatase inhibitor resistance.Nature reviews. Cancer · 2015
   Review
7. Analysis of gene copy number alterations by multiplex ligation-dependent probe amplification in columnar cell lesions of the breast.Cellular oncology (Dordrecht, Netherlands) · 2014
   Article
8. Prognostic and predictive value of copy number alterations in invasive breast cancer as determined by multiplex ligation-dependent probe amplification.Cellular oncology (Dordrecht, Netherlands) · 2014
   Article
9. ESR1 amplification in breast cancer by optimized RNase FISH: frequent but low-level and heterogeneous.PloS one · 2013
   Article

Corrections and comments

• Comment on
  The different roles of ER subtypes in cancer biology and therapy.2011
• Comment on
  ESR1 gene amplification: another mechanism regulating the cellular levels of ERα.2011

Authors and funding

6 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as