Evidence map›Paper›PMID 22270557›Full record

Trial reportFertility and sterility2012

Predictors of pregnancy and live birth after insemination in couples with unexplained or male-factor infertility.

Hao Huang, Karl R Hansen, Pamela Factor-Litvak, Sandra A Carson, David S Guzick, Nanette Santoro, Michael P Diamond, Esther Eisenberg, Heping Zhang, National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Fertility and sterility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Optimizing outcomes in intrauterine insemination: A narrative synthesis of two decades of clinical research (2000-2024).International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Alcohol and fertility: how much is too much?Fertility research and practice · 2017
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Hao HuangDepartment of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA.
Karl R Hansen
Pamela Factor-Litvak
Sandra A Carson
David S Guzick
Nanette Santoro
Michael P Diamond
Esther Eisenberg
Heping Zhang
National Institute of Child Health and Human Development Cooperative Reproductive Medicine Network
Yale University · USColumbia University · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Florida Health Science Center · USUniversity of Oklahoma Health Sciences Center · USVanderbilt University Medical Center · USWayne State University · USWomen & Infants Hospital of Rhode Island · US

Funding

Data Coordination Center for the RMNU10HD055925 · NICHD · YALE UNIVERSITY · PI ZHANG, HEPING · 2007 to 2019
$39.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
GHSU/WSU Cooperative Reproductive Medicine NetworkU10HD039005 · NICHD · WAYNE STATE UNIVERSITY · PI DIAMOND, MICHAEL PETER · 2000 to 2017
$5.2M
Cooperative Multicenter Reproductive Medicine Network (U10)U10HD055936 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SMITH, YOLANDA R · 2007 to 2014
$2.1M
Luteal Progesterone Supplementation in Clomiphene Citrate-IUI CyclesU10HD077680 · NICHD · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HANSEN, KARL RICHARD · 2013 to 2017
$1.5M
NCATS NIH HHS UL1 TR000064NICHD NIH HHS HD55925NICHD NIH HHS U10 HD039005NICHD NIH HHS U10 HD055925NICHD NIH HHS U10 HD055936NICHD NIH HHS U10 HD077680NICHD NIH HHS U10 HD39005
6 · The paper itself

Abstract

objectiveTo identify risk factors for pregnancy outcomes in couples treated with intracervical or intrauterine insemination, with or without superovulation for unexplained or male-factor infertility.

designSecondary analysis of data from a randomized superovulation and intrauterine insemination trial.

settingAcademic medical centers. INTERVENTION(S): Treatment continued for four cycles unless pregnancy was achieved. PATIENT(S): Out of 932 couples randomized to four treatment groups, 664 couples who had completed the lifestyle questionnaires were assessed for occurrence of pregnancy and live birth. MAIN OUTCOME MEASURE(S): Pregnancy and live birth. RESULT(S): The pregnancy and live birth rates were significantly higher in couples in which the female partners reported that they had consumed coffee or tea in the past or drank alcoholic beverages in the past (past users) compared with those who had never consumed coffee, tea, or alcoholic beverages. Past users also had significantly higher pregnancy and live birth rates than those currently consuming coffee or tea or alcoholic beverages. Demographic, occupational exposure, and other lifestyle factors were not significant. CONCLUSION(S): Couples in which the female partners drank coffee, tea, or alcoholic beverages in the past had higher pregnancy and live birth rates compared with never or current users. When discontinuing these habits, they might have made other lifestyle changes to improve the pregnancy outcome.

Indexed as

Insemination, ArtificialLife StyleLive BirthOvulation InductionPregnancy RateAcademic Medical CentersAdultAlcohol DrinkingAlcoholic BeveragesChi-Square DistributionCoffeeFemaleHumansInfertilityInfertility, MaleLogistic ModelsCoffeeTea

Identifiers

PMID22270557
PMCPMC3319287
OpenAlexW2037064744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.