ArticleHistochemistry and cell biology2012
The interaction between CD44 on tumour cells and hyaluronan under physiologic flow conditions: implications for metastasis formation.
Article in Histochemistry and cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- CD44 Modulates Cell Migration and Invasion in Ewing Sarcoma Cells.International journal of molecular sciences · 2023Article
- The material properties of naked mole-rat hyaluronan.Scientific reports · 2019Article
- Article
- Single-Molecule Unbinding Forces between the Polysaccharide Hyaluronan and Its Binding Proteins.Biophysical journal · 2018Article
- Modeling small cell lung cancer (SCLC) biology through deterministic and stochastic mathematical models.Oncotarget · 2018Review
- Fluid shear stress and tumor metastasis.American journal of cancer research · 2018Review
- CD44 mediates the catch-bond activated rolling of HEPG2Iso epithelial cancer cells on hyaluronan.Cell adhesion & migration · 2017Article
- A single molecule assay to probe monovalent and multivalent bonds between hyaluronan and its key leukocyte receptor CD44 under force.Scientific reports · 2016Article
- Cancer metastases: challenges and opportunities.Acta pharmaceutica Sinica. B · 2015Review
- Article
- Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.Advanced drug delivery reviews · 2014Review
- Metastasis review: from bench to bedside.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Cell adhesion molecules in metastatic neuroblastoma models.Clinical & experimental metastasis · 2014Article
- Article
- The Histochemistry and Cell Biology compendium: a review of 2012.Histochemistry and cell biology · 2013Review
- Effects of hyaluronic acid and CD44 interaction on the proliferation and invasiveness of malignant pleural mesothelioma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2012Article
- Therapeutic targeting of hyaluronan in the tumor stroma.Cancers · 2012Article
- Theranostic nanoparticles based on PEGylated hyaluronic acid for the diagnosis, therapy and monitoring of colon cancer.Biomaterials · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The adhesion of tumour cells to the endothelial cells of blood vessels of the microcirculation represents a crucial step in haematogenous metastasis formation. Similar to leukocyte extravasation, selectins mediate initial tumour cell rolling on endothelium. An additional mechanism of leukocyte adhesion to endothelial cells is mediated by hyaluronan (HA). However, data on the interaction of tumour cells with hyaluronan under shear stress are lacking. The expression of the hyaluronan binding protein CD44 on tumour cell surfaces was evaluated using flow cytometry. The adhesion of tumour cells to HA with regard to adhesive events and rolling velocity was determined in flow assays in the human small cell lung cancer (SCLC) cell lines SW2, H69, H82, OH1 and OH3, the colon carcinoma cell line HT29 and the melanoma cell line MeWo. Hyaluronan deposition in human and mouse lung blood vessels was histochemically determined. MeWo adhered best to HA followed by HT29. SCLC cell lines showed the lowest CD44 expression on the cell surface and lowest number of adhesive events. While hyaluronan was deposited in patches in the microvasculature of the alveolar septum in the human lung, it was only present in the periarterial space in the mouse lung. Certain tumour entities bind to HA under physiological shear stresses so that HA can be considered a further ligand for cell extravasation in haematogenous metastasis. As hyaluronan is deposited within the pulmonary microvasculature, it may well serve as a ligand for its binding partner CD44, which is expressed by many tumour cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.