Evidence map›Paper›PMID 22269952›Full record

ReviewNature reviews. Gastroenterology & hepatology2012

Unraveling the mystery of pain in chronic pancreatitis.

Pankaj Jay Pasricha

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 112 citations in OpenAlex.

  1. Trial
  2. Trial
  3. The Mechanism of HDAC2 Inhibitors on Chronic Pancreatitis Pain.Journal of neurological surgery reports · 2025
    Article
  4. Article
  5. Biliary sphincterotomy resets pancreaticobiliary pain refractory to intrasphincteric Botox injections in functional biliary pain.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Article
  6. Pain in chronic pancreatitis: What can we do today?World journal of methodology · 2024
    Review
  7. Review
  8. Review
  9. I Feel! Therefore, I Am from Pain to Consciousness in DOC Patients.International journal of molecular sciences · 2023
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Optical Imaging of Pancreatic Innervation.Frontiers in endocrinology · 2021
    Review
  17. Article
  18. Evolution of nociception and pain: evidence from fish models.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Pankaj Jay PasrichaStanford University School of Medicine, 300 Pasteur Drive, M211 Alway Building, Stanford, CA 94305, USA. pasricha@stanford.edu
Stanford University · US

Funding

Molecular Mechanisms of Pain in Chronic PancreatitisR01DK073558 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PASRICHA, PANKAJ J · 2007 to 2015
$2.7M
NIDDK NIH HHS R01 DK073558
6 · The paper itself

Abstract

Chronic pancreatitis is typically a painful condition and it can be associated with a severe burden of disease. The pathogenesis of pain in this disorder is poorly understood and its treatment has been largely empirical, often consisting of surgical or other invasive methods, with an outcome that is variable and frequently unsatisfactory. Human and experimental studies have indicated a critical role for neuronal mechanisms that result in peripheral and central sensitization. The pancreatic nociceptor seems to be significantly affected in this condition, with increased excitability associated with downregulation of potassium currents. Some of the specific molecules implicated in this process include the vanilloid receptor, TRPV1, nerve growth factor, the protease activated receptor 2 and a variety of others that are discussed in this Review. Studies have also indicated novel therapeutic targets for this condition.

Indexed as

Abdominal PainHumansNociceptorsPancreatitis, Chronic

Identifiers

PMID22269952
OpenAlexW2053403065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.