ArticleCough (London, England)2012
An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome.
Article in Cough (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04073251 (Randomized, Controlled, Double Blind Clinical Study on the Assessment of Efficacy, Safety and Palatability of "KalobaTuss® Children", a Syrup for the Treatment of Cough in Pediatric Age), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized, Controlled, Double Blind Clinical Study on the Assessment of Efficacy, Safety and Palatability of "KalobaTuss® Children", a Syrup for the Treatment of Cough in Pediatric Age (3-6 Years).
Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- Efficacy and safety of the syrup "KalobaTUSS®" as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial.BMC pediatrics · 2021Trial
- Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded, multicenter study.World journal of pediatrics : WJP · 2017Trial
- Cloperastine in paediatric and adult cough management: a historical narrative review.Drugs in context · 2026Review
- Prevalence and Clinical Characteristics of Acute Cough in Indian Pediatric Population: Insights from Real-World Study.Journal of pharmacy & bioallied sciences · 2025Article
- Neuromodulators in Acute and Chronic Cough in Children: An Update from the Literature.International journal of molecular sciences · 2024Review
- Therapeutic principles and unmet needs in the treatment of cough in pediatric patients: review and expert survey.BMC pediatrics · 2023Article
- Cough Remedies for Children and Adolescents: Current and Future Perspectives.Paediatric drugs · 2020Article
- Upper Respiratory Tract Infection-Associated Acute Cough and the Urge to Cough: New Insights for Clinical Practice.Pediatric allergy, immunology, and pulmonology · 2020Review
- Burden of disease in children with respiratory tract infections in primary care: diary-based cohort study.Family practice · 2019Observational
- Acute cough in Italian children: parents' beliefs, approach to treatment, and the family impact.Multidisciplinary respiratory medicine · 2019Article
- Bronchodilators, Antibiotics, and Oral Corticosteroids Use in Primary Care for Children With Cough.Global pediatric health · 2019Article
- Cost of acute cough in Italian children.ClinicoEconomics and outcomes research : CEOR · 2018Article
- Prospective study of the efficacy of antibiotics versus antitussive drugs for the management of URTI-related acute cough in children.Multidisciplinary respiratory medicine · 2016Article
- Does additional antimicrobial treatment have a better effect on URTI cough resolution than homeopathic symptomatic therapy alone? A real-life preliminary observational study in a pediatric population.Multidisciplinary respiratory medicine · 2015Article
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- The difficult coughing child: prolonged acute cough in children.Cough (London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCough is one of the most frequent symptoms in children and is the most common symptom for which children visit a health care provider.
methodsThis is an observational study on acute cough associated with upper respiratory tract infection (URTI) in children. The study evaluates the epidemiology and impact of cough on quality of sleep and children's activities, and the outcome of cough with antitussive treatments in pediatric routine clinical practice. Study assessments were performed through a pediatric cough questionnaire (PCQ), developed by the Italian Society of Cough Study. A total of 433 children visited by family care pediatricians for acute cough due to a URTI were enrolled in this study, with mean age of 6.1 years (SD 3.6). Cough type, duration, severity and frequency, cough impact on sleep disturbances of children and parents and on school and sport activities were assessed at baseline. In a subset of 241 children who were either treated with antitussive drugs (levodropropizine n = 101, central antitussives n = 60) or received no treatment (n = 80), the outcome of cough after 6 days was analyzed in terms of resolution, improvement, no change, or worsening. Descriptive analysis, χ2 test, and multivariate analysis with stepwise logistic regression were performed.
resultsCough disturbed sleep in 88% of children and 72% of parents. In children treated with cough suppressants, the duration, type, intensity, and frequency cough were similar at baseline in the two groups respectively treated with levodropropizine and central antitussives (cloperastine and codeine). Both levodropropizine and central drugs reduced cough intensity and frequency. However, percentage of cough resolution was higher with levodropropizine than with central antitussives (47% vs. 28% respectively, p = 0.0012).
conclusionsAcute cough disturbs sleep in most children and their parents. Both levodropropizine and central antitussives reduced cough intensity, with levodropropizine producing a higher cough resolution rate.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.