Evidence map›Paper›PMID 22269720›Full record

ArticleThe Annals of thoracic surgery2012

Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy.

Eric J Velazquez, Judson B Williams, Eric Yow, Linda K Shaw, Kerry L Lee, Harry R Phillips, Christopher M O'Connor, Peter K Smith, Robert H Jones

Open access · greenAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Annals of thoracic surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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  12. Mechanical support for high-risk coronary artery bypass grafting.Indian journal of thoracic and cardiovascular surgery · 2018
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Eric J VelazquezDivision of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA. eric.velazquez@duke.edu
Judson B Williams
Eric Yow
Linda K Shaw
Kerry L Lee
Harry R Phillips
Christopher M O'Connor
Peter K Smith
Robert H Jones
Duke Medical Center · USClinical Research Institute · US

Funding

STICHESR01HL105853 · NHLBI · DUKE UNIVERSITY · PI AL-KHALIDI, HUSSEIN · 2011 to 2015
$10.2M
Postdoctoral Training in Cardiovascular Clinical ResearchT32HL069749 · NHLBI · DUKE UNIVERSITY · PI MARK, DANIEL B · 2003 to 2023
$6.7M
NHLBI NIH HHS R01 HL105853NHLBI NIH HHS T32 HL069749NHLBI NIH HHS T32-HL069749
6 · The paper itself

Abstract

backgroundWe prospectively applied the Surgical Treatment of Ischemic Cardiomyopathy trial entry criteria to an observational database to determine whether coronary artery bypass grafting (CABG) decreases mortality compared with medical therapy (MED) for patients with coronary artery disease and depressed left ventricular ejection fraction.

methodsThis was a retrospective, observational, cohort study of prospectively collected data from the Duke Databank for Cardiovascular Disease. Long-term mortality was the main outcome measure. Between January 1, 1995, and July 31, 2009, 86,874 patients underwent cardiac catheterization for suspected ischemic heart disease and were evaluated for inclusion in the analysis.

resultsA total of 2,624 patients were found to have left ventricular ejection fraction less than 0.35, coronary artery disease amenable to CABG, and no left main stenosis of greater than 50%. After exclusions including ongoing Canadian Cardiovascular Society class III angina and acute myocardial infarction, 763 patients were included for propensity score analysis, including 624 who received MED and 139 who underwent CABG. Adjusted mortality curves were constructed for those patients in the three quintiles most likely to receive CABG. The curves diverged early, with risk-adjusted mortality rates at 5 years of 46% for MED versus 29% for CABG, and the survival benefit of CABG over MED continued through 10 years of follow-up (hazard ratio, 0.63; 95% confidence interval, 0.45 to 0.88).

conclusionsAmong a propensity-matched, risk-adjusted, observational cohort of patients with coronary artery disease, left ventricular ejection fraction less than 0.35, and no left main disease of greater than 50%, CABG is associated with a survival advantage over MED through 10 years of follow-up.

Indexed as

Coronary Artery BypassAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCardiovascular AgentsComorbidityDatabases, FactualFemaleFollow-Up StudiesHeart FailureHumansKaplan-Meier EstimateMaleMiddle AgedMitral Valve InsufficiencyModels, CardiovascularCardiovascular Agents

Identifiers

PMID22269720
PMCPMC3638256
OpenAlexW1987074350

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.