Evidence map›Paper›PMID 22269592›Full record

Trial reportArchives of internal medicine2012

A randomized controlled trial of positive-affect intervention and medication adherence in hypertensive African Americans.

Gbenga O Ogedegbe, Carla Boutin-Foster, Martin T Wells, John P Allegrante, Alice M Isen, Jared B Jobe, Mary E Charlson

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of internal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 131 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 15 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00227175 completednot on this map

Cornell Translational Behavioral Science Research Consortium: Hypertension Qualitative Study

TypeobservationalSponsorWeill Medical College of Cornell UniversityRan2003 to 2003Enrolled60ConditionsHypertensionArmsSemi-structured, open ended interview
NCT00248872 nacompletednot on this map

A Randomized Trial of Changing Medication Adherence In Hypertensive African-American Patients

TypeinterventionalSponsorWeill Medical College of Cornell UniversityRan2004 to 2008Enrolled278ConditionsHypertensionArmsIntervention Group
NCT07414732 narecruitingnot on this mapstarted 2026, after this paper: background citation

The "Savvy for Stroke Survivors" Study: Testing a Novel Tool to Help Stroke Survivors Take Their Medication

TypeinterventionalSponsorMassachusetts General HospitalRan2026 to 2027Enrolled150ConditionsStroke, Intracerebral Haemorrhage, Ischemic Stroke, TIA (Transient Ischemic Attack)ArmsSavvy Medication Adherence Intervention
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 15 syntheses or guidelines pooled it, 235 citations in OpenAlex.

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  7. Positive affect and medication adherence in chronic conditions: A systematic review.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019
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  12. Interventions for enhancing medication adherence.The Cochrane database of systematic reviews · 2014
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  14. Interventions to increase medication adherence in African-American and Latino populations: a literature review.Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health · 2014
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gbenga O OgedegbeNew York Univeristy School of Medicine, New York, NY 10010, USA. Olugbenga.Ogedegbe@nyumc.org
Carla Boutin-Foster
Martin T Wells
John P Allegrante
Alice M Isen
Jared B Jobe
Mary E Charlson
New York University · US

Funding

Trial Using Motivational Interviewing Positive Affect and Self-Affirmation in HyP60MD003421 · NIMHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BOUTIN-FOSTER, CARLA, CHARLSON, MARY E · 2009 to 2013
$8.9M
TRANSLATIONAL BEHAVIORAL SCIENCE RESEARCH CONSORTIA-N01HC25196N01HC025196 · HC · WEILL MEDICAL COLLEGE · PI CHARLSON, MARY E · 2004 to 2006
–
NHLBI NIH HHS N01 HC025196NIMHD NIH HHS P60 MD003421
6 · The paper itself

Abstract

backgroundPoor adherence explains poor blood pressure (BP) control; however African Americans suffer worse hypertension-related outcomes.

methodsThis randomized controlled trial evaluated whether a patient education intervention enhanced with positive-affect induction and self-affirmation (PA) was more effective than patient education (PE) alone in improving medication adherence and BP reduction among 256 hypertensive African Americans followed up in 2 primary care practices. Patients in both groups received a culturally tailored hypertension self-management workbook, a behavioral contract, and bimonthly telephone calls designed to help them overcome barriers to medication adherence. Also, patients in the PA group received small gifts and bimonthly telephone calls to help them incorporate positive thoughts into their daily routine and foster self-affirmation. The main outcome measures were medication adherence (assessed with electronic pill monitors) and within-patient change in BP from baseline to 12 months.

resultsThe baseline characteristics were similar in both groups: the mean BP was 137/82 mm Hg; 36% of the patients had diabetes; 11% had stroke; and 3% had chronic kidney disease. Based on the intention-to-treat principle, medication adherence at 12 months was higher in the PA group than in the PE group (42% vs 36%, respectively; P =.049). The within-group reduction in systolic BP (2.14 mm Hg vs 2.18 mm Hg; P = .98) and diastolic BP (-1.59 mm Hg vs -0.78 mm Hg; P = .45) for the PA group and PE group, respectively, was not significant.

conclusionsA PE intervention enhanced with PA led to significantly higher medication adherence compared with PE alone in hypertensive African Americans. Future studies should assess the cost-effectiveness of integrating such interventions into primary care. Trial Registration clinicaltrials.gov Identifier: NCT00227175.

Indexed as

HypertensionMedication AdherenceAgedAntihypertensive AgentsBlack or African AmericanBlood PressureCognitive Behavioral TherapyDisease ManagementFemaleHealth Status DisparitiesHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePatient Education as TopicPrimary Health CareAntihypertensive Agents

Identifiers

PMID22269592
PMCPMC4669680
OpenAlexW2135465619

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.