SynthesisCanadian journal of surgery. Journal canadien de chirurgie2012
Meta-analysis of the effectiveness of prophylactic antibiotics in the prevention of postoperative complications after tension-free hernioplasty.
Synthesis in Canadian journal of surgery. Journal canadien de chirurgie, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Antibiotic prophylaxis for prevention of postoperative wound infection in adults undergoing open elective inguinal or femoral hernia repair.The Cochrane database of systematic reviews · 2020Pooled it
- Network meta-analysis of antibiotic prophylaxis for prevention of surgical-site infection after groin hernia surgery.The British journal of surgery · 2017Pooled it
- Clinical application of fast-track surgery with Chinese medicine treatment in the devascularization operation for cirrhotic portal hypertension.Chinese journal of integrative medicine · 2015Trial
- Application of machine learning algorithms to predict postoperative surgical site infections and surgical site occurrences following inguinal hernia surgery.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- Identification of mixed anaerobic infections after inguinal hernia repair based on metagenomic next-generation sequencing: A case report.Open medicine (Warsaw, Poland) · 2024Article
- Practical Mouse Model to Investigate Therapeutics for Staphylococcusaureus Contaminated Surgical Mesh Implants.The Journal of surgical research · 2023Article
- Asymptomatic mesh infection 6 years after laparoscopic totally extraperitoneal inguinal hernia repair: A rare case report.Clinical case reports · 2022Article
- USA Department of Defense audit of surgical antibiotic prophylaxis prescribing patterns in inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2021Article
- Predictive factors for the development of surgical site infection in adults undergoing initial open inguinal hernia repair.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Inguinal hernia repair in Nigeria: a survey of surgical trainees.Hernia : the journal of hernias and abdominal wall surgery · 2019Article
- The effectiveness of i.v. cefuroxime prophylaxis of surgical site infection after elective inguinal hernia repair with mesh: A retrospective observational study.European journal of clinical pharmacology · 2016Observational
- Do we need antibiotic prophylaxis in endoscopic inguinal hernia repair? Results of the Herniamed Registry.Surgical endoscopy · 2015Article
- The danger of performing meta-analysis and the impact of guidelines.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
- Use of antibiotic prophylaxis in elective inguinal hernia repair in adults in London and south-east England: a cross-sectional survey.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
- Does topical rifampicin reduce the risk of surgical field infection in hernia repair?Ulusal cerrahi dergisi · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious reviews of the effectiveness of antibiotic prophylaxis for elective inguinal hernia repair were not conclusive owing to the limited number of patients enrolled in randomized controlled trials (RCTs). However, since new RCTs involving patients undergoing tention-free hernioplasty have been published in recent years, we performed a new meta-analysis to evaluate the effectiveness of antibiotic prophylaxisin the prevention of postoperative complications after this procedure.
methodsWe performed a meta-analysis of RCTs studying the use of antibiotic prophylaxis to prevent postoperative complications in patients undergoing tension-free hernioplasty.
resultsWe included 6 RCTs conducted around the world in our analysis. Compared with the control condition, antibiotic prophylaxis was associated with a lower incidence of incision infection (odds ratio [OR] 0.45, 95% confidence interval [CI] 0.26-0.77, p = 0.004). There were no significant differences in risk for incision hematoma (OR 1.57, 95% CI 0.60-4.10, p = 0.35), respiratory infection (OR 1.00, 95% CI 0.17-5.79, p > 0.99) or urinary tract infection (OR 1.81, 95% CI 0.38-8.52, p = 0.45) between the 2 conditions.
conclusionAntibiotic prophylaxis use in patients undergoing tension-free hernioplasty decreases the rate of incision infection by 55%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.