ArticleBMC infectious diseases2012
Granulomatous hepatitis due to Bartonella henselae infection in an immunocompetent patient.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Ultrasound features of visceral cat scratch disease: a rare case of granulomatous hepatosplenic bartonellosis in an immunocompetent patient.Journal of ultrasound · 2026Article
- Experimental Infection of Ferrets withPathogens (Basel, Switzerland) · 2025Article
- Clinical and epidemiological characteristics of cat scratch disease in children from southwestern China: a retrospective analysis of mNGS-confirmed cases.Frontiers in public health · 2025Article
- Bacteremia caused byQuantitative imaging in medicine and surgery · 2024Article
- Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs.Frontiers in microbiology · 2024Article
- Blood Supplementation Enhances Bartonella henselae Growth and Molecular Detection of Bacterial DNA in Liquid Culture.Microbiology spectrum · 2023Article
- Severe acute hepatitis in children: Proposal to investigate Bartonella henselae with a multistep platform.PLoS neglected tropical diseases · 2022Article
- Cryptogenic hepatitis patients have a higher Bartonella sp.-DNA detection in blood and skin samples than patients with non-viral hepatitis of known cause.PLoS neglected tropical diseases · 2022Article
- Article
- A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract.Gastroenterology research and practice · 2021Review
- Hepatosplenic Cat Scratch Disease: Description of Two CasesSN comprehensive clinical medicine · 2021Review
- Hepatosplenic bartonellosis in immunocompetent adults: a case series and literature review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2020Observational
- Article
- Hepatosplenic abscesses in an immunocompetent child with cat-scratch disease from Peru.Annals of clinical microbiology and antimicrobials · 2019Article
- Article
- Emerging Infections and Pertinent Infections Related to Travel for Patients with Primary Immunodeficiencies.Journal of clinical immunology · 2017Review
- Pyogranulomatous Pancarditis with Intramyocardial Bartonella henselae San Antonio 2 (BhSA2) in a Dog.Journal of veterinary internal medicine · 2017Article
- Did Bartonella henselae contribute to the deaths of two veterinarians?Parasites & vectors · 2015Article
- Bilateral mandibular pyogranulomatous lymphadenitis and pulmonary nodules in a dog with Bartonella henselae bacteremia.The Canadian veterinary journal = La revue veterinaire canadienne · 2014Article
- Hepatosplenic cat scratch disease in immunocompetent adults: report of 3 cases and review of the literature.Medicine · 2014Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBartonella henselae (B. henselae) is considered a rare cause of granulomatous hepatitis. Due to the fastidious growth characteristics of the bacteria, the limited sensitivity of histopathological stains, and the non-specific histological findings on liver biopsy, the diagnosis of hepatic bartonellosis can be difficult to establish. Furthermore, the optimal treatment of established hepatic bartonellosis remains controversial. CASE PRESENTATION: We present a case of hepatic bartonellosis in an immunocompetent woman who presented with right upper quadrant pain and a five cm right hepatic lobe mass on CT scan. The patient underwent a right hepatic lobectomy. Surgical pathology revealed florid necrotizing granulomatous hepatitis, favoring an infectious etiology. Despite extensive histological and serological evaluation a definitive diagnosis was not established initially. Thirteen months after initial presentation, hepatic bartonellosis was diagnosed by PCR studies from surgically excised liver tissue. Interestingly, the hepatic granulomas persisted and Bartonella henselae was isolated from the patient's enriched blood culture after several courses of antibiotic therapy.
conclusionThe diagnosis of hepatic bartonellosis is exceedingly difficult to establish and requires a high degree of clinical suspicion. Recently developed, PCR-based approaches may be required in select patients to make the diagnosis. The optimal antimicrobial therapy for hepatic bartonellosis has not been established, and close follow-up is needed to ensure successful eradication of the infection.
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