ArticleMicrocirculation (New York, N.Y. : 1994)2012
Neurovascular proximity in the diaphragm muscle of adult mice.
Article in Microcirculation (New York, N.Y. : 1994), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Calcium Signaling in Schwann cells.Neuroscience letters · 2020Review
- Ageing of the Diaphragm Muscle.Cureus · 2020Review
- Postnatal Development and Distribution of Sympathetic Innervation in Mouse Skeletal Muscle.International journal of molecular sciences · 2018Article
- Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.Development (Cambridge, England) · 2014Article
- Anatomic connections of the diaphragm: influence of respiration on the body system.Journal of multidisciplinary healthcare · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
objectiveRegional blood flow to the diaphragm muscle varies with the workload of inspiration. To provide anatomical insight into coupling between muscle fiber recruitment and oxygen supply, we tested whether arterioles are physically associated with motor nerve branches of the diaphragm.
methodsFollowing vascular casting, intact diaphragm muscles of C57BL/6 and CD-1 mice were stained for motor innervation. Arteriolar networks and nerve networks were mapped (~2 μm resolution) to evaluate their physical proximity.
resultsNeurovascular proximity was similar between muscle regions and mouse strains. Of total mapped nerve lengths (C57BL/6, 70 ± 15 mm; CD-1, 87 ± 13 mm), 80 ± 14% and 67 ± 10% were ≤250 μm from the nearest arteriole and associated predominantly with arterioles ≤45 μm in diameter. Distances to the nearest arteriole encompassing 50% of total nerve length (D(50)) were consistently within 200 μm. With nerve networks repositioned randomly within muscle borders, D(50) values nearly doubled (p < 0.05). Reference lines within anatomical boundaries reduced proximity to arterioles (p < 0.05) as they deviated from the original location of motor nerves.
conclusionAcross two strains of mice, motor nerves and arterioles of the diaphragm muscle are more closely associated than can be explained by chance. We hypothesize that neurovascular proximity facilitates local perfusion upon muscle fiber recruitment.
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