Evidence map›Paper›PMID 22268493›Full record

ReviewMedical mycology2012

Quorum sensing in fungi--a review.

Patrícia Albuquerque, Arturo Casadevall

Abstract readReview
In one paragraph

Review in Medical mycology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 416 citations in OpenAlex.

  1. Review
  2. Discovery of functional compounds from dimorphic edibleSynthetic and systems biotechnology · 2026
    Article
  3. Bacilli the most important biocontrol agent in Brazilian agriculture: from mechanisms of action to market adoption.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Review
  4. Hydralazine potentiates the antiproliferative effect of photodynamic therapy on Candida albicans and Candida parapsilosis in vitro.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  5. Review
  6. 2'-Deoxyuridine-promoted infection inApplied and environmental microbiology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Cyclodextrins in action: ModulatingBiotechnology reports (Amsterdam, Netherlands) · 2025
    Article
  15. Review
  16. Review
  17. Article
  18. A cell-cell communication signal fromApplied and environmental microbiology · 2025
    Article
  19. Article
  20. Article

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Patrícia AlbuquerqueDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA. patricia.andrade@phd.einstein.yu.edu
Arturo Casadevall
Albert Einstein College of Medicine · USUniversidade de Brasília · BR

Funding

Synergy of Host Defense Mechanisms in the LungR01HL059842 · NHLBI · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1997 to 2023
$7.4M
Biology of Fungal MelaninR01AI052733 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 2003 to 2019
$6.6M
PROTECTIVE ANTIBODIES FOR CRYPTOCOCCAL INFECTIONSR01AI033774 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2014
$5.6M
Molecular Characterization of C. neoformans AntibodiesR37AI033142 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CASADEVALL, ARTURO · 2007 to 2016
$3.9M
MOLECULAR CHARACTERIZATION OF C NEOFORMANS ANTIBODIESR01AI033142 · NIAID · YESHIVA UNIVERSITY · PI CASADEVALL, ARTURO · 1994 to 2006
$1.7M
NHLBI NIH HHS 5R01HL059842NHLBI NIH HHS R01 HL059842NIAID NIH HHS 5R01AI033774NIAID NIH HHS 5R01AI052733NIAID NIH HHS 5R37AI033142NIAID NIH HHS R01 AI033142NIAID NIH HHS R01 AI033774NIAID NIH HHS R01 AI052733NIAID NIH HHS R37 AI033142
6 · The paper itself

Abstract

Quorum sensing (QS) is a mechanism of microbial communication dependent on cell density that can regulate several behaviors in bacteria such as secretion of virulence factors, biofilm formation, competence and bioluminescence. The existence of fungal QS systems was revealed ten years ago after the discovery that farnesol controls filamentation in the pathogenic polymorphic fungus Candida albicans. In the past decade, farnesol has been shown to play multiple roles in C. albicans physiology as a signaling molecule and inducing detrimental effects on host cells and other microbes. In addition to farnesol, the aromatic alcohol tyrosol was also found to be a C. albicans QS molecule (QSM) controlling growth, morphogenesis and biofilm formation. In Saccharomyces cerevisiae, two other aromatic alcohols, phenylethanol and tryptophol were found to be QSMs regulating morphogenesis during nitrogen starvation conditions. Additionally, population density-dependent behaviors that resemble QS have been described in several other fungal species. Although fungal QS research is still in its infancy, its discovery has changed our views about the fungal kingdom and could eventually lead to the development of new antifungal therapeutics.

Indexed as

Gene Expression Regulation, FungalQuorum SensingAdaptation, PhysiologicalFungi

Identifiers

PMID22268493
PMCPMC4294699
OpenAlexW2126599529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.