ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Effect of exercise training on biologic vascular age in healthy seniors.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- The effect of 1 year of Alagebrium and moderate-intensity exercise training on left ventricular function during exercise in seniors: a randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial.Experimental gerontology · 2013Trial
- Different types of exercise and myocardial angiogenesis regulation: A scoping review of cardiac-specific evidence in animal models.Physiological reports · 2026Article
- The Role and Mechanism of Gut Microbiota and Metabolites in Vascular Calcification.International journal of molecular sciences · 2026Review
- Effects of aging and endurance exercise training on cardiorespiratory fitness and cardiac structure and function in healthy midlife and older women.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Ursolic acid enhances the effect of exercise training on vascular aging by reducing oxidative stress in aged type 2 diabetic rats.Food science & nutrition · 2023Article
- Effect of Aquatic Exercise Training on Aortic Hemodynamics in Middle-Aged and Elderly Adults.Frontiers in cardiovascular medicine · 2021Article
- The effect of lifelong endurance exercise on cardiovascular structure and exercise function in women.The Journal of physiology · 2020Article
- Plasma matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs and aging and lifelong exercise adaptations in ventricular and arterial stiffness.Experimental gerontology · 2019Article
- Exercise and Arterial Stiffness in the Elderly: A Combined Cross-Sectional and Randomized Controlled Trial (EXAMIN AGE).Frontiers in physiology · 2019Article
- The effect of lifelong exercise frequency on arterial stiffness.The Journal of physiology · 2018Article
- Age related vascular endothelial function following lifelong sedentariness: positive impact of cardiovascular conditioning without further improvement following low frequency high intensity interval training.Physiological reports · 2015Article
- Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2.Journal of magnetic resonance imaging : JMRI · 2013Article
- Shorter term aerobic exercise improves brain, cognition, and cardiovascular fitness in aging.Frontiers in aging neuroscience · 2013Article
- The effect of pre-competition training on biochemical indices and immune function of volleyball players.International journal of clinical and experimental medicine · 2013Article
- Alagebrium in combination with exercise ameliorates age-associated ventricular and vascular stiffness.Experimental gerontology · 2012Article
- How to Care for Adolescent Patients With Orthostatic Intolerance in the Primary Care Office.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Arteriosclerosis with aging leads to central arterial stiffening in humans, which could be a prime cause for increased cardiac afterload in the elderly. The purpose of the present study was to assess the effects of 1 yr of progressive exercise training on central aortic compliance and left ventricular afterload in sedentary healthy elderly volunteers. Ten healthy sedentary seniors and 11 Masters athletes (>65 yr) were recruited. The sedentary seniors underwent 1 yr of progressive exercise training so that at the end of the year, they were exercising ∼200 min/wk. Central aortic compliance was assessed by the Modelflow aortic age, which reflects the intrinsic structural components of aortic compliance. Cardiac afterload was assessed by effective arterial elastance (Ea) with its contributors of peripheral vascular resistance (PVR) and systemic arterial compliance (SAC). After exercise training, Ea, PVR, and SAC were improved in sedentary seniors and became comparable with those of Masters athletes although the Modelflow aortic age was not changed. Moreover, after exercise training, when stroke volume was restored with lower body negative pressure back to pretraining levels, the exercise training-induced improvements in Ea, PVR, and SAC were eliminated. Aortic stiffening with aging was not improved even after 1 yr of progressive endurance exercise training in the previously sedentary elderly, while left ventricular afterload was reduced. This reduced afterload after exercise training appeared to be attributable to cardiovascular functional modulation to an increase in stroke volume rather than to intrinsic structural changes in the arterial wall.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.