ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Expansion of the fetoplacental vasculature in late gestation is strain dependent in mice.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- CSF1R+ Macrophages and Osteoclasts Are Essential for Limb Bone Development During Embryogenesis.Journal of developmental biology · 2026Article
- Acid sphingomyelinase is a gatekeeper of placental labyrinthine architecture and function.Development (Cambridge, England) · 2025Article
- Maternal exposure to polyethylene micro- and nanoplastics impairs umbilical blood flow but not fetal growth in pregnant mice.Scientific reports · 2024Article
- Preconception paternal alcohol exposure decreases IVF embryo survival and pregnancy success rates in a mouse model.Molecular human reproduction · 2023Article
- Allometric scaling relationships in mouse placenta.Journal of the Royal Society, Interface · 2022Article
- Placental metabolite profiles in late gestation for healthy mice.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- Interpretation of Wave Reflections in the Umbilical Arterial Segment of the Feto-Placental Circulation: Computational Modeling of the Feto-Placental Arterial Tree.IEEE transactions on bio-medical engineering · 2021Article
- Maternal background alters the penetrance of growth phenotypes and sex-specific placental adaptation of offspring sired by alcohol-exposed males.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Male fetal sex affects uteroplacental angiogenesis in growth restriction mouse model†.Biology of reproduction · 2021Article
- Placental vascular abnormalities in the mouse alter umbilical artery wave reflections.American journal of physiology. Heart and circulatory physiology · 2019Article
- Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse.The Journal of physiology · 2018Article
- Analytical model of the feto-placental vascular system: consideration of placental oxygen transport.Royal Society open science · 2018Article
- Arterio-venous fetoplacental vascular geometry and hemodynamics in the mouse placenta.Placenta · 2017Article
- Ultrasound detection of altered placental vascular morphology based on hemodynamic pulse wave reflection.American journal of physiology. Heart and circulatory physiology · 2017Article
- Placental Origins of Chronic Disease.Physiological reviews · 2016Review
- A longitudinal study of placental perfusion using dynamic contrast enhanced magnetic resonance imaging in murine pregnancy.Placenta · 2016Article
- Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures.Cell adhesion & migration · 2016Article
- Longitudinal Changes in Placental Magnetic Resonance Imaging Relaxation Parameter in Murine Pregnancy: Compartmental Analysis.Gynecologic and obstetric investigation · 2016Article
- Placental changes caused by food restriction during early pregnancy in mice are reversible.Reproduction (Cambridge, England) · 2015Article
- Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.PLoS pathogens · 2015Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
How the fetoplacental arterial tree grows and expands during late gestational development is largely unknown. In this study, we quantified changes in arterial branching in the fetal exchange region of the mouse placenta during late gestation, when capillarization increases rapidly. We studied two commonly used mouse strains, CD1 and C57Bl/6 (B6), at embryonic days (E)13.5, 15.5, and 17.5. B6 mice differ from CD1 mice by exhibiting a blunted fetal weight gain in late gestation. We found that B6 capillarization and interhemal membrane thinning were reduced and placental hypoxia-inducible factor-1α and VEGF-A expression were higher than CD1 near term. Automated vascular segmentation of microcomputed tomography data sets revealed that the number of arterial vessels ≥50 μm remained constant during late gestation in both strains, despite large increases in downstream capillary volume quantified by stereology (+65% in B6 mice and +200% in CD1 mice). Arterial diameters expanded in both strains from E13.5 to E15.5; however, diameters continued to expand to E17.5 in B6 mice only. The diameter scaling coefficient at branch sites was near optimal (-3.0) and remained constant in CD1 mice, whereas it decreased, becoming abnormal, in B6 mice at term (-3.5 ± 0.2). Based on arterial tree geometry, resistance remained constant throughout late gestation (∼0.45 mmHg·s·μl(-1)) in CD1 mice, whereas it decreased by 50% in late gestation in B6 mice. Quantification of the fetoplacental vasculature revealed significant strain-dependent differences in arterial and capillary expansion in late gestation. In both strains, enlargement of the fetoplacental arterial tree occurred primarily by increased arterial diameters with no change in segment numbers in late gestation.
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