Trial reportAJNR. American journal of neuroradiology2012
Differentiation of hemorrhage from iodinated contrast in different intracranial compartments using dual-energy head CT.
Trial report in AJNR. American journal of neuroradiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
103 citing papers in PubMed, 5 syntheses or guidelines pooled it, 214 citations in OpenAlex.
- Diagnostic accuracy of dual-energy CT in distinguishing intracerebral hemorrhage from contrast staining: a systematic review and meta-analysis with radiation dose assessment.La Radiologia medica · 2026Pooled it
- Diagnostic performance of dual-energy CT for differentiating acute intracranial hemorrhage from contrast staining: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Diagnostic accuracy of dual-energy computed tomography in the diagnosis of neurological complications after endovascular treatment of acute ischaemic stroke: a systematic review and meta-analysis.The British journal of radiology · 2024Pooled it
- Diagnostic accuracy of dual-energy computed tomography to differentiate intracerebral hemorrhage from contrast extravasation after endovascular thrombectomy for acute ischemic stroke: systematic review and meta-analysis.European radiology · 2022Pooled it
- Dual-energy CT for differentiating acute intracranial hemorrhage from contrast staining or calcification: a meta-analysis.Neuroradiology · 2020Pooled it
- Evaluation of iodine detection and quantification limits in photon-counting CT-a phantom study.European radiology experimental · 2026Article
- Subarachnoid contrast staining not attributable to endovascular therapy.Emergency radiology · 2026Article
- From Iodine Maps to Brain Window Images: Quantitative Visibility Thresholds of Iodine Staining Using Photon-Counting CT-A Retrospective Observational Study.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Imaging insights in veno-venous and veno-arterial extracorporeal membrane oxygenation (ECMO): CT protocols, underlying pathophysiology, and main complications.Insights into imaging · 2025Article
- The delayed spectral sign in Post-transfer CT imaging: an imaging marker of stroke severity and hemorrhagic risk.Neuroradiology · 2025Article
- Italian radiologists and dual-energy CT: a state of the art from a shared document by the computed tomography subspecialty section of the Italian society of radiology.La Radiologia medica · 2025Article
- AI-Assisted Edema Map Optimization Improves Infarction Detection in Twin-Spiral Dual-Energy CT.Brain sciences · 2025Article
- Iodine-Based Dual-Energy Computed Tomography After Mechanical Thrombectomy Predicts Secondary Neurologic Decline from Cerebral Edema After Severe Stroke.Neurocritical care · 2025Observational
- Change in Emergency Department Length of Stay following Routine Adoption of Dual-Energy CT to Differentiate Intracranial Hemorrhage from Calcification.AJNR. American journal of neuroradiology · 2025Article
- Severe contrast-induced encephalopathy diagnosed with postmortem dual-energy CT in an elderly patient.Radiology case reports · 2025Article
- Evaluation of pure subarachnoid hemorrhage after mechanical thrombectomy in a series of 781 consecutive patients.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Contrast-induced encephalopathy after coil embolization for a ruptured anterior communicating artery aneurysm with perfusion from bilaterally developed A1 segments.Surgical neurology international · 2025Article
- Assessment of commercially available artificial intelligence software for differentiating hemorrhage from contrast on head CT following thrombolysis for ischemic stroke.Frontiers in neurology · 2025Article
- Spectral optimization using fast kV switching and filtration for photon counting CT with realistic detector responses: a simulation study.Journal of medical imaging (Bellingham, Wash.) · 2024Article
43 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIdentification of ICH, particularly after ischemic stroke therapy, is important for guiding subsequent antithrombotic management and is often confounded by contrast staining or extravasations within intracerebral or extra-axial compartments. This study evaluates the accuracy of DECT in distinguishing ICH from iodinated contrast in patients who received contrast via IA or IV delivery. MATERIALS AND
methodsForty patients who had received IA or IV contrast were evaluated using a DECT scanner at 80kV and 140kV to distinguish hyperdensities secondary to contrast staining or extravasation from those representing ICH. A 3-material decomposition algorithm was used to obtain virtual noncontrast images and iodine overlay images. Sensitivity, specificity, and accuracy of DECT in prospectively distinguishing intracranial contrast from hemorrhage within parenchymal, subarachnoid, extra-axial, intraventricular, and intra-arterial compartments were computed using routine clinical follow-up imaging as the standard of reference.
resultsA total of 148 foci of intracranial hyperattenuation were identified. Of these, 142 were correctly classified for the presence of hemorrhage by DECT. The sensitivity, specificity, and accuracy for identifying hemorrhage, depending on the compartment being considered, were 100%, 84.4%-100%, and 87.2%-100%, respectively. The only instances where DECT failed to correctly identify the source of hyperattenuation was in the presence of diffuse parenchymal calcification (n = 5) and a metallic streak artifact (n = 1).
conclusionAfter IA and/or IV contrast administration, DECT can accurately differentiate all types of ICH from iodinated contrast without employing any additional radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.