ArticleInternational journal of nanomedicine2011
Nanostructured model implants for in vivo studies: influence of well-defined nanotopography on de novo bone formation on titanium implants.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- The next frontier in osseointegration: energy and speed as critical determinants and their enhancement by UV photofunctionalization.International journal of implant dentistry · 2025Article
- Investigating Immunomodulatory Biomaterials for Preventing the Foreign Body Response.Bioengineering (Basel, Switzerland) · 2023Review
- Periosteal topology creates an osteo-friendly microenvironment for progenitor cells.Materials today. Bio · 2023Article
- Functionalization with Polyphenols of a Nano-Textured Ti Surface through a High-Amino Acid Medium: A Chemical-Physical and Biological Characterization.Nanomaterials (Basel, Switzerland) · 2022Article
- Molecular Response to Nanopatterned Implants in the Human Jaw Bone.ACS biomaterials science & engineering · 2021Article
- Importance of Surface Topography in Both Biological Activity and Catalysis of Nanomaterials: Can Catalysis by Design Guide Safe by Design?International journal of molecular sciences · 2021Review
- Pheochromocytoma (PC12) Cell Response on Mechanobactericidal Titanium Surfaces.Materials (Basel, Switzerland) · 2018Article
- Nanomaterials for Tissue Engineering In Dentistry.Nanomaterials (Basel, Switzerland) · 2016Review
- Bone regenerating effect of surface-functionalized titanium implants with sustained-release characteristics of strontium in ovariectomized rats.International journal of nanomedicine · 2016Article
- The role of well-defined nanotopography of titanium implants on osseointegration: cellular and molecular events in vivo.International journal of nanomedicine · 2016Article
- Article
- Nanotechnology in dentistry: prevention, diagnosis, and therapy.International journal of nanomedicine · 2015Review
- Nanotopography directs mesenchymal stem cells to osteoblast lineage through regulation of microRNA-SMAD-BMP-2 circuit.Journal of cellular physiology · 2014Article
- Surface characteristics of and in vitro behavior of osteoblast-like cells on titanium with nanotopography prepared by high-energy shot peening.International journal of nanomedicine · 2014Article
- Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro.International journal of nanomedicine · 2014Article
- Influence of nanomaterials on stem cell differentiation: designing an appropriate nanobiointerface.International journal of nanomedicine · 2012Review
- Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An implantable model system was developed to investigate the effects of nanoscale surface properties on the osseointegration of titanium implants in rat tibia. Topographical nanostructures with a well-defined shape (semispherical protrusions) and variable size (60 nm, 120 nm and 220 nm) were produced by colloidal lithography on the machined implants. Furthermore, the implants were sputter-coated with titanium to ensure a uniform surface chemical composition. The histological evaluation of bone around the implants at 7 days and 28 days after implantation was performed on the ground sections using optical and scanning electron microscopy. Differences between groups were found mainly in the new bone formation process in the endosteal and marrow bone compartments after 28 days of implantation. Implant surfaces with 60 nm features demonstrated significantly higher bone-implant contact (BIC, 76%) compared with the 120 nm (45%) and control (57%) surfaces. This effect was correlated to the higher density and curvature of the 60 nm protrusions. Within the developed model system, nanoscale protrusions could be applied and systematically varied in size in the presence of microscale background roughness on complex screw-shaped implants. Moreover, the model can be adapted for the systematic variation of surface nanofeature density and chemistry, which opens up new possibilities for in vivo studies of various nanoscale surface-bone interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.