ArticleThe European respiratory journal2012
Respiratory impairment and COPD hospitalisation in older persons: a competing risk analysis.
Article in The European respiratory journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations.Journal of the American Geriatrics Society · 2016Trial
- Respiratory impairment and dyspnea and their associations with physical inactivity and mobility in sedentary community-dwelling older persons.Journal of the American Geriatrics Society · 2014Trial
- Parametric Estimation of the Mean Number of Events in the Presence of Competing Risks.Biometrical journal. Biometrische Zeitschrift · 2025Article
- Chronic obstructive pulmonary disease burden, grades and erythrocytosis at a tertiary hospital in western Uganda.BMC pulmonary medicine · 2024Article
- GPs should not try to detect mild COPD.NPJ primary care respiratory medicine · 2020Article
- Enhanced risk of traumatic brain injury in patients with chronic obstructive pulmonary disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2020Article
- FEVRespiratory care · 2020Article
- Re-evaluation of combination therapy in chronic obstructive pulmonary disease (COPD).Respiratory medicine · 2019Article
- Article
- The subsequent course of disability in older persons discharged to a skilled nursing facility after an acute hospitalization.Experimental gerontology · 2017Article
- Spirometry, Static Lung Volumes, and Diffusing Capacity.Respiratory care · 2017Article
- Aging-Related Considerations When Evaluating the Forced Expiratory Volume in 1 Second (FEV1) Over Time.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Phenotype of Spirometric Impairment in an Aging Population.American journal of respiratory and critical care medicine · 2016Article
- Review
- Phenotype of normal spirometry in an aging population.American journal of respiratory and critical care medicine · 2015Article
- Comment on: Wollmer P, Engström G. Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV1/VC: An outcome study. Respiratory Medicine (2013) 107, 1460-1462.: Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV1/VC.Respiratory medicine · 2015Article
- Respiratory symptoms, spirometric respiratory impairment, and respiratory disease in middle-aged and older persons.Journal of the American Geriatrics Society · 2015Article
- Article
- Respiratory impairment in older persons: when less means more.The American journal of medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The aim of the present study was to evaluate, among older persons, the association between respiratory impairment and hospitalisation for chronic obstructive pulmonary disease (COPD), based on spirometric Z-scores, i.e. the LMS (lambda, mu, sigma) method, and a competing risk approach. Using data on 3,563 white participants aged 65-80 yrs (from the Cardiovascular Health Study) we evaluated the association of LMS-defined respiratory impairment with the incident of COPD hospitalisation and the competing outcome of death without COPD hospitalisation, over a 5-yr period. Respiratory impairment included airflow limitation (mild, moderate or severe) and restrictive pattern. Over a 5-yr period, 276 (7.7%) participants had a COPD hospitalisation incident, whereas 296 (8.3%) died without COPD hospitalisation. The risk of COPD hospitalisation was elevated more than two-fold in LMS-defined mild and moderate airflow limitation and restrictive pattern (adjusted HR (95% CI): 2.25 (1.25-4.05), 2.54 (1.53- 4.22) and 2.65 (1.82-3.86), respectively), and more than eight-fold in LMS-defined severe airflow limitation (adjusted HR (95% CI) 8.33 (6.24-11.12)). Conversely, only LMS-defined restrictive-pattern was associated with the competing outcome of death without COPD hospitalisation (adjusted HR (95% CI) 1.68 (1.22-2.32)). In older white persons, LMS-defined respiratory impairment is strongly associated with an increased risk of COPD hospitalisation. These results support the LMS method as a basis for defining respiratory impairment in older persons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.