SynthesisOccupational and environmental medicine2012
Neurobehavioral performance among agricultural workers and pesticide applicators: a meta-analytic study.
Synthesis in Occupational and environmental medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Pooled it
- Chronic exposure to organophosphate (OP) pesticides and neuropsychological functioning in farm workers: a review.International journal of occupational and environmental health · 2016Pooled it
- Effects of Pesticide Exposure on Cognitive Functions in Agricultural Workers: A Systematic Review.Florence Nightingale journal of nursing · 2026Article
- Ethnic and Sex Differences in the Association Between Organochlorine Exposure and Cognitive Function in Late Life.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Association of pesticide exposure with neurobehavioral outcomes among avocado farmworkers in Mexico.International journal of hygiene and environmental health · 2024Article
- Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction.International journal of molecular sciences · 2024Review
- Investigation of acute organophosphate poisoning in humans based on sociodemographic and role of neurotransmitters with survival study in South India.Scientific reports · 2022Article
- Association between pesticide exposure and neurobehavioral performance of agricultural workers: A cross-sectional study.Brain and behavior · 2022Article
- Secondhand tobacco smoke, does it have an impact on the neurobehavioral performance of the exposed children?Environmental science and pollution research international · 2020Article
- Reduced neurobehavioral functioning in agricultural workers and rural inhabitants exposed to pesticides in northern Chile and its association with blood biomarkers inhibition.Environmental health : a global access science source · 2020Article
- Monitoring of the Organophosphate Pesticide Chlorpyrifos in Vegetable Samples from Local Markets in Northern Thailand by Developed Immunoassay.International journal of environmental research and public health · 2020Article
- Magnitude of behavioral deficits varies with job-related chlorpyrifos exposure levels among Egyptian pesticide workers.Neurotoxicology · 2020Article
- Progression of intervention-focused research for Gulf War illness.Military Medical Research · 2019Review
- Knowledge and Practices of Safe Use of Pesticides among a Group of Farmers in Northern Iran.The international journal of occupational and environmental medicine · 2019Article
- Neuropsychological Findings in Gulf War Illness: A Review.Frontiers in psychology · 2019Review
- Neurochemical and Behavioral Dysfunctions in Pesticide Exposed Farm Workers: A Clinical Outcome.Indian journal of clinical biochemistry : IJCB · 2018Review
- Occupational exposure to pesticides: development of a job-exposure matrix for use in population-based studies (PESTIPOP).Journal of exposure science & environmental epidemiology · 2018Article
- Pesticide Application and Khat Chewing as Predictors of the Neurological Health Outcomes among Pesticide Applicators in a Vector Control Unit, Saudi Arabia.The international journal of occupational and environmental medicine · 2018Article
- Pharmacologically increasing microtubule acetylation corrects stress-exacerbated effects of organophosphates on neurons.Traffic (Copenhagen, Denmark) · 2017Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Chronic low level exposure of agricultural workers and applicators to pesticides has been found to be associated with different degrees of decrement in cognitive and psychomotor functions. The goal of this study was to use meta-analysis to (1) identify and quantify neurobehavioral deficits among agricultural workers and pesticide applicators, and (2) analyse the potential confounders or moderators of these neurobehavioral deficits. Seventeen studies, reporting on 21 independent cohort groups, were included in the meta-analysis. These studies involved 16 neuropsychological tests providing 23 different performance measures that constitute the neurobehavioral constructs. All tests and measures of the neurobehavioral functions of attention, visuomotor integration, verbal abstraction and perception constructs showed significant decrements for exposed participants. One out of three tests of memory, two of five tests of sustained attention, and four of eight tests of motor speed constructs also showed significant decrements. Nine out of these 15 effect size distributions demonstrated significant heterogeneity across cohorts. A search for cohort-level variables (eg, agricultural workers vs applicators, duration of exposure, age and percentage of male participants) to explain this heterogeneity was largely unsuccessful. However, for one test, Block Design, the duration of exposure was positively associated with performance decrements. Furthermore, it was also found that performance decrements on this test were smaller for older participants. Increasing the number of studies and using more consistent methodologies in field studies are needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.