ArticleJournal of applied physiology (Bethesda, Md. : 1985)2012
Effect of sex and ovarian hormones on carotid baroreflex resetting and function during dynamic exercise in humans.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Feedback from group III/IV afferents in skeletal muscle slows heart rate acceleration when transitioning from rest to low-intensity exercise in males.Experimental physiology · 2026Article
- Brachial blood flow and pressure responses are unrelated to the greater isometric handgrip tolerance of females compared to males.Physiological reports · 2026Article
- Repeatability of heart-rate variability and baroreflex sensitivity as metrics of cardiac autonomic function during exercise in young females and males.European journal of applied physiology · 2026Article
- Cardiac autonomic function in young, healthy adults: Influence of race and sex.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Influence of endogenous and exogenous hormones on the cardiovascular response to lower extremity exercise and group III/IV activation in young females.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Cardiovascular adjustments to cold pressor test in postmenopausal women and the impact of α1-adrenergic blockade.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Central modulation of cardiac baroreflex moment-to-moment sensitivity during treadmill exercise in conscious cats.Physiological reports · 2022Article
- Sex differences in integrated neurocardiovascular control of blood pressure following acute intermittent hypercapnic hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Cerebrovascular responses to graded exercise in young healthy males and females.Physiological reports · 2020Article
- Gender Differences in Hemodynamic Regulation and Cardiovascular Adaptations to Dynamic Exercise.Current cardiology reviews · 2020Review
- Sex differences in baroreflex function in health and disease.The journal of physiological sciences : JPS · 2019Review
- Sex differences in the ventilatory and cardiovascular response to supine and tilted metaboreflex activation.Physiological reports · 2019Article
- Impaired carotid baroreflex control of arterial blood pressure in multiple sclerosis.Journal of neurophysiology · 2016Article
- Leptin differentially increases sympathetic nerve activity and its baroreflex regulation in female rats: role of oestrogen.The Journal of physiology · 2015Article
- An afferent explanation for sexual dimorphism in the aortic baroreflex of rat.American journal of physiology. Heart and circulatory physiology · 2014Article
- Yes! Sex matters: sex, the brain and blood pressure.Current hypertension reports · 2014Review
- Effect of aging on carotid baroreflex control of blood pressure and leg vascular conductance in women.American journal of physiology. Heart and circulatory physiology · 2014Article
- Effects of Ovarian Cycle on Hemodynamic Responses during Dynamic Exercise in Sedentary Women.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Short-term administration of progesterone and estradiol independently alter carotid-vasomotor, but not carotid-cardiac, baroreflex function in young women.American journal of physiology. Heart and circulatory physiology · 2013Article
- New insights into the effects of age and sex on arterial baroreflex function at rest and during dynamic exercise in humans.Autonomic neuroscience : basic & clinical · 2012Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
To date, no studies have examined whether there are either sex- or ovarian hormone-related alterations in arterial baroreflex resetting and function during dynamic exercise. Thus we studied 16 young men and 18 young women at rest and during leg cycling at 50% heart rate (HR) reserve. In addition, 10 women were studied at three different phases of the menstrual cycle. Five-second pulses of neck pressure (NP) and neck suction (NS) from +40 to -80 Torr were applied to determine full carotid baroreflex (CBR) stimulus response curves. An upward and rightward resetting of the CBR function curve was observed during exercise in all groups with a similar magnitude of CBR resetting for mean arterial pressure (MAP) and HR between sexes (P > 0.05) and at different phases of the menstrual cycle (P > 0.05). For CBR control of MAP, women exhibited augmented pressor responses to NP at rest and exercise during mid-luteal compared with early and late follicular phases. For CBR control of HR, there was a greater bradycardic response to NS in women across all menstrual cycle phases with the operating point (OP) located further away from centering point (CP) on the CBR-HR curve during rest (OP-CP; in mmHg: -13 ± 3 women vs. -3 ± 3 men; P < 0.05) and exercise (in mmHg: -31 ± 2 women vs. -15 ± 3 men; P < 0.05). Collectively, these findings suggest that sex and fluctuations in ovarian hormones do not influence exercise resetting of the baroreflex. However, women exhibited greater CBR control of HR during exercise, specifically against acute hypertension, an effect that was present throughout the menstrual cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.