Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

206 citing papers in PubMed, 15 syntheses or guidelines pooled it.

1. The efficacy of antidepressant medication versus interpersonal psychotherapy for depression in middle-aged women: a systematic review and individual participant data meta-analysis.Archives of women's mental health · 2026
   Pooled it
2. Performance of exome sequencing in premature ovarian insufficiency: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026
   Pooled it
3. Pharmacogenomic studies of fertility outcomes in pediatric cancer survivors - A systematic review.Clinical and translational science · 2024
   Pooled it
4. Genetic associations with age of menopause in familial longevity.Menopause (New York, N.Y.) · 2019
   Pooled it
5. Association between age at menopause and fracture risk: a systematic review and meta-analysis.Endocrine · 2019
   Pooled it
6. Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.Human molecular genetics · 2018
   Pooled it
7. The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.PloS one · 2018
   Pooled it
8. Recommendations for Premature Ovarian Insufficiency Surveillance for Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Report From the International Late Effects of Childhood Cancer Guideline Harmonization Group in Collaboration With the PanCareSurFup Consortium.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016
   Guideline
9. BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging.Biology of reproduction · 2015
   Pooled it
10. Genetic studies of body mass index yield new insights for obesity biology.Nature · 2015 · on this map
    Pooled it
11. New genetic loci link adipose and insulin biology to body fat distribution.Nature · 2015
    Pooled it
12. Pleiotropic genes for metabolic syndrome and inflammation.Molecular genetics and metabolism · 2014
    Pooled it
13. Meta-analysis of loci associated with age at natural menopause in African-American women.Human molecular genetics · 2014
    Pooled it
14. DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.Human molecular genetics · 2014
    Pooled it
15. A genome-wide association study of early menopause and the combined impact of identified variants.Human molecular genetics · 2013
    Pooled it
16. Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume.Human reproduction (Oxford, England) · 2015
    Trial
17. Human fertility, molecular genetics, and natural selection in modern societies.PloS one · 2015
    Trial
18. NEMP1 organizes the meiotic telomere-LINC interface to control chromosome movement and telomere integrity.bioRxiv : the preprint server for biology · 2026
    Article
19. Reproductive Lifespan and Adult-Onset Bronchiectasis in U.S. Postmenopausal Women: An Investigation of the Women's Health Initiative Cohort.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
    Article
20. Exploring the Shared Genetic Basis of Age at Menopause and Osteoarthritis.ACR open rheumatology · 2026
    Article

146 more citing papers are in PubMed but not listed here.

Corrections and comments

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Authors and funding

180 authors.

Funding

Abstract

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