ArticleChemMedChem2012
Discovery of 2-(2-benzoxazoyl amino)-4-aryl-5-cyanopyrimidine as negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu₅): from an artificial neural network virtual screen to an in vivo tool compound.
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Article in ChemMedChem, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
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Who cites it
24 citing papers in PubMed.
- Pharmacology, Signaling and Therapeutic Potential of Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.ACS pharmacology & translational science · 2024Review
- Review of Personalized Medicine and Pharmacogenomics of Anti-Cancer Compounds and Natural Products.Genes · 2024Review
- Biotechnological Innovations from Ocean: Transpiring Role of Marine Drugs in Management of Chronic Disorders.Molecules (Basel, Switzerland) · 2022Review
- Identification of Novel HBV/HDV Entry Inhibitors by Pharmacophore- and QSAR-Guided Virtual Screening.Viruses · 2021Article
- Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors.Viruses · 2021Article
- Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.Frontiers in pharmacology · 2020Review
- Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.ACS chemical neuroscience · 2019Article
- Kinetic and system bias as drivers of metabotropic glutamate receptor 5 allosteric modulator pharmacology.Neuropharmacology · 2019Article
- Computational Drug Design Applied to the Study of Metabotropic Glutamate Receptors.Molecules (Basel, Switzerland) · 2019Review
- In Silico HCT116 Human Colon Cancer Cell-Based Models En Route to the Discovery of Lead-Like Anticancer Drugs.Biomolecules · 2018Article
- Review
- In Silico Studies in Drug Research Against Neurodegenerative Diseases.Current neuropharmacology · 2018Review
- QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery.Frontiers in pharmacology · 2018Article
- Cannabinoid Receptor 1 and Fatty Acid Amide Hydrolase Contribute to Operant Sensation Seeking in Mice.International journal of molecular sciences · 2017Article
- Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes.Bioorganic & medicinal chemistry letters · 2016Article
- N-Alkylpyrido[1',2':1,5]pyrazolo-[4,3-d]pyrimidin-4-amines: A new series of negative allosteric modulators of mGlu1/5 with CNS exposure in rodents.Bioorganic & medicinal chemistry letters · 2016Article
- Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.Neoplasia (New York, N.Y.) · 2015Article
- Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety.Bioorganic & medicinal chemistry letters · 2014Article
- Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.ACS chemical neuroscience · 2014Article
- Computational methods in drug discovery.Pharmacological reviews · 2014Review
Corrections and comments
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Authors and funding
19 authors.
Ralf MuellerDepartment of Chemistry, Vanderbilt University, 7330 Stevenson Center, Station B 351822, Nashville, TN 37232-6600, USA.
Eric S Dawson
Jens Meiler
Alice L Rodriguez
Brian A Chauder
Brittney S Bates
Andrew S Felts
Jeffrey P Lamb
Usha N Menon
Sataywan B Jadhav
Alexander S Kane
Carrie K Jones
Karen J Gregory
Colleen M Niswender
P Jeffrey Conn
Christopher M Olsen
Danny G Winder
Kyle A Emmitte
Craig W Lindsley
Funding
The Vanderbilt Specialized Chemistry Center for Accelerated Probe DevelopmentU54MH084659 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2008 to 2013
$24.1MREGULATION OF SIGNALING BY MGLUR5R01MH062646 · NIMH · VANDERBILT UNIVERSITY · PI P Jeffrey Conn, COLLEEN M NISWENDER · 2001 to 2026
$10.9MVanderbilt NCDDDG for Discovery of Novel Treatments for SchizophreniaU01MH087965 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2010 to 2014
$9.3MFUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2MLead Optimization & Development of Back-Up mGlu5 NAM Candidates for Treatment ofU19MH097056 · NIMH · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2013 to 2015
$3.8MPartial Antagonists of mGluR5 for Treatment of Cocaine AddictionR01DA023947 · NIDA · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2008 to 2012
$2.1MCheminformatics of Allosteric mGluR Modulation promotes Therapeutic DevelopmentR01MH090192 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2010 to 2013
$1.5MNovel Schizophrenia Therapeutics By Virtual High-Throughput ScreeningR21MH082254 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2008 to 2009
$364kNIDA NIH HHS R01 DA023947NIDA NIH HHS R01DA023947-01NIMH NIH HHS R01 MH062646NIMH NIH HHS R01 MH090192NIMH NIH HHS R01MH090192-01NIMH NIH HHS R21 MH082254NIMH NIH HHS U01 MH087965NIMH NIH HHS U19 MH097056NIMH NIH HHS U54 MH084659NINDS NIH HHS R01 NS031373
Abstract
PubMed holds no abstract for this paper.
Indexed as
Allosteric RegulationAnimalsAnxiety DisordersBehavior, AnimalBenzoxazolesBrainDrug DiscoveryGlutamic AcidHEK293 CellsHigh-Throughput Screening AssaysHumansInjections, IntraperitonealMiceMice, Inbred C57BLNeural Networks, ComputerPsychotropic DrugsBenzoxazolesGlutamic AcidPsychotropic DrugsPyrimidinesReceptor, Metabotropic Glutamate 5Receptors, Metabotropic GlutamateSmall Molecule Libraries
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.